Constance J. Temm

Table S5: Description of the patients and characteristics of their tumors (n=597)

Table S4: Breast cancers with TONSL amplification selectively overexpress genes associated with E2F targets, G2/M checkpoint, mitotic spindle and mTORC1 pathways.

Table S9: Results of ATAC-seq of primary and TONSL-immortalized cells.

Table S1: Gene expression differences between primary and hTERT-immortalized breast epithelial cell lines.

Table S10: Results of RNA-seq analysis of primary and TONSL-immortalized cells. Fold differences in expression are shown.

Table S7: Univariable analysis of other tumor markers for overall and progression-free survival

Table S6: Bivariate analysis of TONSL H-score with other tumor markers

Table S2: Gene expression differences between mature luminal and luminal progenitor cells of the breast. Data are from 15 samples, five each from women of European, African and Latina ancestry.

Table S13: Enrichment of binding sites for NF-kB and p53 in chromatin regions that become accessible or closed, respectively, upon TONSL overexpression. Genes names and chromatin positions are indicated.

Table S14: Genes differentially expressed in TMD-436pLKO and TMD-436shTONSL cells. Fold changes in gene expression are indicated.