Hui-Hui Lin
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Hui-Hui Lin has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- A-Mei Huang
Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan
1 shared publication - Chien-Sheng Wang
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 800-852, Taiwan
1 shared publication - Ching-Chia Li
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
1 shared publication - Hung-Lung Ke
Department of Urology Kaohsiung Medical University Hospital Kaohsiung Taiwan
1 shared publication - Jhen-Hao Jhan
Department of Urology Brigham and Women's Hospital & Harvard Medical School Boston Massachusetts USA
1 shared publication - Wei-Chi Hsu
Department of Urology, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan
1 shared publication
Latest Publications
- Open Access
MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1
Little is known regarding the molecular characterization of upper tract urothelial carcinoma (UTUC). Novel therapeutic targets and prognostic predictors are imminent. In the present study, we aim to examine the oncogenic function and molecular mechanism of Derlin-1 in UTUC. Derlin-1 overexpression is significantly associated with poor prognosis in patients with UTUC. In vitro, knockdown or over-expression of Derlin-1 markedly regulated UTUC cell invasion and migration. We further discovered miR-375-3p suppresses cell invasion and migration by inversely regulating Derlin-1 and blocking EMT in UTUC cells. Taking this together, miR-375-3p functions as a tumor suppressive microRNA by directly targeting Derlin-1 and blocking epithelial–mesenchymal transition (EMT) in UTUC.
Open AccessMicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1
Little is known regarding the molecular characterization of upper tract urothelial carcinoma (UTUC). Novel therapeutic targets and prognostic predictors are imminent. In the present study, we aim to examine the oncogenic function and molecular mechanism of Derlin-1 in UTUC. Derlin-1 overexpression is significantly associated with poor prognosis in patients with UTUC. In vitro, knockdown or over-expression of Derlin-1 markedly regulated UTUC cell invasion and migration. We further discovered miR-375-3p suppresses cell invasion and migration by inversely regulating Derlin-1 and blocking EMT in UTUC cells. Taking this together, miR-375-3p functions as a tumor suppressive microRNA by directly targeting Derlin-1 and blocking epithelial–mesenchymal transition (EMT) in UTUC.