Chrit T. W. Moonen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Chrit T. W. Moonen has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Baudouin Denis de Senneville
Laboratory for Molecular and Functional Imaging: From Physiology to Therapy, UMR 5231 CNRS/Université Bordeaux 2, Bordeaux, France
1 shared publication - Bruno Quesson
CHU Bordeaux, IHU Lyric, Université de Bordeaux, Bordeaux, France
1 shared publication - Franck Couillaud
Molecular and Functional Imaging, ERT-CNRS 5543, Université Victor Segalen, Bordeaux, France
1 shared publication Josette Arsaut
Laboratory for Molecular and Functional Imaging: From Physiology to Therapy, Unité Mixte de Recherche 5231, Centre National de la Recherche Scientifique/University Victor Segalen Bordeaux, 146 Rue Leo Saignat, Case 117, 33076 Bordeaux, France; and
1 shared publication- Mario Ries
Laboratory for Molecular and Functional Imaging CNRS University Segalen Bordeaux 146 rue Leo Saignat Case 117 33076 Bordeaux France
1 shared publication - Roel Deckers
Division of Imaging & Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
1 shared publication
Latest Publications
- Open Access
MRI-Guided High Intensity Focused Ultrasound of Liver and Kidney
High Intensity Focused Ultrasound (HIFU) can be used to achieve a local temperature increase deep inside the human body in a non-invasive way. MRI guidance of the procedure allows in situ target definition. In addition, MRI can be used to provide continuous temperature mapping during HIFU for spatial and temporal control of the heating procedure and prediction of the final lesion based on the received thermal dose. Temperature mapping of mobile organs as kidney and liver is challenging, as well as real-time processing methods for feedback control of the HIFU procedure. In this paper, recent technological advances are reviewed in MR temperature mapping of these organs, in motion compensation of the HIFU beam, in intercostal HIFU sonication, and in volumetric ablation and feedback control strategies. Recent pre-clinical studies have demonstrated the feasibility of each of these novel methods. The perspectives to translate those advances into the clinic are addressed. It can be concluded that MR guided HIFU for ablation in liver and kidney appears feasible but requires further work on integration of technologically advanced methods.
Open AccessMRI-Guided High Intensity Focused Ultrasound of Liver and Kidney
High Intensity Focused Ultrasound (HIFU) can be used to achieve a local temperature increase deep inside the human body in a non-invasive way. MRI guidance of the procedure allows in situ target definition. In addition, MRI can be used to provide continuous temperature mapping during HIFU for spatial and temporal control of the heating procedure and prediction of the final lesion based on the received thermal dose. Temperature mapping of mobile organs as kidney and liver is challenging, as well as real-time processing methods for feedback control of the HIFU procedure. In this paper, recent technological advances are reviewed in MR temperature mapping of these organs, in motion compensation of the HIFU beam, in intercostal HIFU sonication, and in volumetric ablation and feedback control strategies. Recent pre-clinical studies have demonstrated the feasibility of each of these novel methods. The perspectives to translate those advances into the clinic are addressed. It can be concluded that MR guided HIFU for ablation in liver and kidney appears feasible but requires further work on integration of technologically advanced methods.
- 27 January 2009
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 106 (4) , 1175-1180
Image-guided, noninvasive, spatiotemporal control of gene expression
Spatiotemporal control of transgene expression is of paramount importance in gene therapy. Here, we demonstrate the use of magnetic resonance temperature imaging (MRI)-guided, high-intensity focused ultrasound (HIFU) in combination with a heat-inducible promoter [heat shock protein 70 (HSP70)] for the in vivo spatiotemporal control of transgene activation. Local gene activation induced by moderate hyperthermia in a transgenic mouse expressing luciferase under the control of the HSP70 promoter showed a high similarity between the local temperature distribution in vivo and the region emitting light. Modulation of gene expression is possible by changing temperature, duration, and location of regional heating. Mild heating protocols (2 min at 43°C) causing no tissue damage were sufficient for significant gene activation. The HSP70 promoter was shown to be induced by the local temperature increase and not by the mechanical effects of ultrasound. Therefore, the combination of MRI-guided HIFU heating and transgenes under control of heat-inducible HSP promoter provides a direct, noninvasive, spatial control of gene expression via local hyperthermia.
- 27 January 2009
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 106 (4) , 1175-1180
Image-guided, noninvasive, spatiotemporal control of gene expression
Spatiotemporal control of transgene expression is of paramount importance in gene therapy. Here, we demonstrate the use of magnetic resonance temperature imaging (MRI)-guided, high-intensity focused ultrasound (HIFU) in combination with a heat-inducible promoter [heat shock protein 70 (HSP70)] for the in vivo spatiotemporal control of transgene activation. Local gene activation induced by moderate hyperthermia in a transgenic mouse expressing luciferase under the control of the HSP70 promoter showed a high similarity between the local temperature distribution in vivo and the region emitting light. Modulation of gene expression is possible by changing temperature, duration, and location of regional heating. Mild heating protocols (2 min at 43°C) causing no tissue damage were sufficient for significant gene activation. The HSP70 promoter was shown to be induced by the local temperature increase and not by the mechanical effects of ultrasound. Therefore, the combination of MRI-guided HIFU heating and transgenes under control of heat-inducible HSP promoter provides a direct, noninvasive, spatial control of gene expression via local hyperthermia.