Anama Di Prinzio

OBJETIVO: Describir la prevalencia y las características epidemiológicas y clínicas de pacientes con prurigo crónico. MÉTODOS: Estudio descriptivo, de corte transversal, en pacientes adultos suscritos al Programa de Atención Médica del Hospital Italiano de Buenos Aires, Argentina (PMHI), entre 1 de enero de 2018 al 1 de enero de 2023. RESULTADOS: Se registraron 132,535 pacientes, de los que 144 padecías prurigo crónico; 105 (73%) eran mujeres con mediana de edad de 67.5 años (RIC 51-79). La prevalencia puntual de prurigo crónico fue de 0.11% (IC95%: 0.09-0.13%), significativamente mayor en mujeres que en hombres (0.13% [IC95%: 0.11-0.16%] vs 0.07% [IC95%: 0.05-0.09%], p<0.0006). Las manifestaciones más frecuentes fueron pápulas (90%) y excoriaciones (84.7%), seguido de placas (21.5%) y nódulos (18.7%). La mediana hasta el diagnóstico fue de 168 días (RIC 36-765). El tratamiento más prescrito fueron los emolientes, corticosteroides tópicos y antihistamínicos. CONCLUSIONES: La prevalencia del PC en nuestra cohorte difiere de la comunicada en otros países. A diferencia de estudios previos, no se evidenciaron asociaciones estadísticamente significativas con otras enfermedades cutáneas. El tratamiento que recibieron los pacientes fue discordante con el propuesto en las guías internacionales. PALABRAS CLAVE: Prurigo; Prurito; Prevalencia; Epidemiología; Argentina

Necrolytic migratory erythema (NME) is a rare disease characterized by painful, pruritic, and migratory reddish-brown plaques and papules, vesicles, blisters, and erosions. It usually affects the periorificial, intertriginous, and acral areas, although it can involve any area of the body. The lesions are usually evanescent and can mimic other conditions such as eczema, psoriasis, or infections, making its diagnosis complex. This disease is associated with glucagonoma in 90% of cases and with other diseases in the remaining 10%. Its evolution is related to the progression of these underlying conditions. Therefore, once diagnosed, studies are recommended to identify and treat associated diseases. We report two clinical cases of adult patients in whom the discovery of this disease and the diagnosis of pancreatic neoplasia were made simultaneously.

Bazex syndrome is a paraneoplastic disorder most commonly linked to squamous cell carcinomas of the upper aerodigestive tract, followed by lung cancer and other malignancies. It manifests through three stages of skin involvement that mirror the tumor's progression. Remarkably, skin lesions precede tumor symptoms or diagnosis in two-thirds of cases, underscoring the crucial role of suspecting this condition as it can promptly reveal an underlying neoplasm. Treatment primarily focuses on addressing the root neoplasm, with recurrent skin lesions potentially indicating tumor relapse. In this context, we present a clinical case involving a male patient whose manifestation of this syndrome facilitated the timely diagnosis of lung adenocarcinoma. This case underscores the significance of understanding this uncommon syndrome and its link to cancer, enabling early and accurate oncological diagnosis.