Fanding Gao
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Fanding Gao has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Fan Song
Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management College of Plant Protection, China Agricultural University, Beijing, China
1 shared publication - Hu Li
State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China
1 shared publication - Li Tian
State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University , Beijing 100193
1 shared publication - Ling Ma
Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China
1 shared publication - Tianfang Wang
School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore, Australia
1 shared publication - Wanzhi Cai
State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China
1 shared publication
Latest Publications
- Open Access
Proteotranscriptomic Analysis and Toxicity Assay Suggest the Functional Distinction between Venom Gland Chambers in Twin-Spotted Assassin Bug, Platymeris biguttatus
Assassin bugs use their salivary venoms for various purposes, including defense, prey paralyzation, and extra-oral digestion, but the mechanisms underlying the functional complexity of the venom remain largely unclear. Since venom glands are composed of several chambers, it is suggested that individual chambers may be specialized to produce chemically distinct venoms to exert different functions. The current study assesses this hypothesis by performing toxicity assays and transcriptomic and proteomic analysis on components from three major venom gland chambers including the anterior main gland (AMG), the posterior main gland (PMG), and the accessory gland (AG) of the assassin bug Platymeris biguttatus. Proteotranscriptomic analysis reveals that AMG and PMG extracts are rich in hemolytic proteins and serine proteases, respectively, whereas transferrin and apolipophorin are dominant in the AG. Toxicity assays reveal that secretions from different gland chambers have distinct effects on the prey, with that from AG compromising prey mobility, that from PMG causing prey death and liquifying the corpse, and that from AMG showing no significant physiological effects. Our study reveals a functional cooperation among venom gland chambers of assassin bugs and provides new insights into physiological adaptations to venom-based predation and defense in venomous predatory bugs.
Open AccessProteotranscriptomic Analysis and Toxicity Assay Suggest the Functional Distinction between Venom Gland Chambers in Twin-Spotted Assassin Bug, Platymeris biguttatus
Assassin bugs use their salivary venoms for various purposes, including defense, prey paralyzation, and extra-oral digestion, but the mechanisms underlying the functional complexity of the venom remain largely unclear. Since venom glands are composed of several chambers, it is suggested that individual chambers may be specialized to produce chemically distinct venoms to exert different functions. The current study assesses this hypothesis by performing toxicity assays and transcriptomic and proteomic analysis on components from three major venom gland chambers including the anterior main gland (AMG), the posterior main gland (PMG), and the accessory gland (AG) of the assassin bug Platymeris biguttatus. Proteotranscriptomic analysis reveals that AMG and PMG extracts are rich in hemolytic proteins and serine proteases, respectively, whereas transferrin and apolipophorin are dominant in the AG. Toxicity assays reveal that secretions from different gland chambers have distinct effects on the prey, with that from AG compromising prey mobility, that from PMG causing prey death and liquifying the corpse, and that from AMG showing no significant physiological effects. Our study reveals a functional cooperation among venom gland chambers of assassin bugs and provides new insights into physiological adaptations to venom-based predation and defense in venomous predatory bugs.