Anna-Lena B.G. Vigil

Figure S11 shows glucose uptake assays.

Figure S7 shows Western blot analysis confirming the findings with RPPA.

Table S4 shows screening results of BKIDCs tested at 10 µM in LNCaP95 and PC3 cells in the MTS assay.

Table S7 shows pharmacokinetic parameters after a single dose in mouse, rat, dog, and cynomolgus monkey.

Table S3 shows PrP and PP-based BKIDC chemical structures.

Figure S1 shows evaluation of Hexokinase activity using LNCaP crude extracts and recombinant enzyme.

Table S6 shows in vitro AMPK activity.

Figure S3 shows competitive proteomic profiling of 1553-N-Me.

Supplementary Image shows uncropped Western blot images.

Table S2 shows rat cardiovascular assessment (nonGLP) after IV administration of increasing dosages of BKIDC-1553.