Melinda Fitzgerald
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Melinda Fitzgerald has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Brittney R. Lins
Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada
1 shared publication - Carole Bartlett
Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia
1 shared publication - Chidozie C. Anyaegbu
Curtin Medical Research Institute, L3 Ralph and Patricia Sarich Neuroscience Research Institute, Curtin University, Nedlands, WA, Australia; Perron Institute for Neurological and Translational Science, L1 Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia
1 shared publication - Harrison Szemray
Australian National Phenome Centre, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia
1 shared publication - Kerry Leggett
University of Western Australia
1 shared publication - Luke Whiley
School of Diagnostic and Therapeutic Sciences, Curtin University , Perth, WA 6102
1 shared publication
Latest Publications
- Open Access
- 2 April 2022
- Published by MDPI AG in Metabolites
- Vol. 12 (4) , 322
Plasma Lipid Profiles Change with Increasing Numbers of Mild Traumatic Brain Injuries in Rats
Mild traumatic brain injury (mTBI) causes structural, cellular and biochemical alterations which are difficult to detect in the brain and may persist chronically following single or repeated injury. Lipids are abundant in the brain and readily cross the blood-brain barrier, suggesting that lipidomic analysis of blood samples may provide valuable insight into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to examine plasma lipid concentrations at 11 days following sham (no injury), one (1×) or two (2×) mTBI in rats. Eighteen lipid species were identified that distinguished between sham, 1× and 2× mTBI. Three distinct patterns were found: (1) lipids that were altered significantly in concentration after either 1× or 2× F mTBI: cholesterol ester CE (14:0) (increased), phosphoserine PS (14:0/18:2) and hexosylceramide HCER (d18:0/26:0) (decreased), phosphoinositol PI(16:0/18:2) (increased with 1×, decreased with 2× mTBI); (2) lipids that were altered in response to 1× mTBI only: free fatty acid FFA (18:3 and 20:3) (increased); (3) lipids that were altered in response to 2× mTBI only: HCER (22:0), phosphoethanolamine PE (P-18:1/20:4 and P-18:0/20:1) (increased), lysophosphatidylethanolamine LPE (20:1), phosphocholine PC (20:0/22:4), PI (18:1/18:2 and 20:0/18:2) (decreased). These findings suggest that increasing numbers of mTBI induce a range of changes dependent upon the lipid species, which likely reflect a balance of damage and reparative responses.
- 2 April 2022
- Published by MDPI AG in Metabolites
- Vol. 12 (4) , 322
Open AccessPlasma Lipid Profiles Change with Increasing Numbers of Mild Traumatic Brain Injuries in Rats
Mild traumatic brain injury (mTBI) causes structural, cellular and biochemical alterations which are difficult to detect in the brain and may persist chronically following single or repeated injury. Lipids are abundant in the brain and readily cross the blood-brain barrier, suggesting that lipidomic analysis of blood samples may provide valuable insight into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to examine plasma lipid concentrations at 11 days following sham (no injury), one (1×) or two (2×) mTBI in rats. Eighteen lipid species were identified that distinguished between sham, 1× and 2× mTBI. Three distinct patterns were found: (1) lipids that were altered significantly in concentration after either 1× or 2× F mTBI: cholesterol ester CE (14:0) (increased), phosphoserine PS (14:0/18:2) and hexosylceramide HCER (d18:0/26:0) (decreased), phosphoinositol PI(16:0/18:2) (increased with 1×, decreased with 2× mTBI); (2) lipids that were altered in response to 1× mTBI only: free fatty acid FFA (18:3 and 20:3) (increased); (3) lipids that were altered in response to 2× mTBI only: HCER (22:0), phosphoethanolamine PE (P-18:1/20:4 and P-18:0/20:1) (increased), lysophosphatidylethanolamine LPE (20:1), phosphocholine PC (20:0/22:4), PI (18:1/18:2 and 20:0/18:2) (decreased). These findings suggest that increasing numbers of mTBI induce a range of changes dependent upon the lipid species, which likely reflect a balance of damage and reparative responses.