Clara Diaz-Requena
Research Subjects
Research Interests
Clara Diaz-Requena has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Anna Vidal-Alabró
Universitat de Barcelona
1 shared publication - Francisco Gomez-Preciado
Department of Nephrology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), 08907 Hospitalet de Llobregat, Barcelona, Spain
1 shared publication - Joan Torras
Department of Nephrology, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Universitario de Bellvitge, Barcelona, Spain
1 shared publication - Juliana Draibe
Bellvitge Biomedical Research Institute (IDIBELL)
1 shared publication - Laura Martinez Valenzuela
Servicio de Nefrologia, Hospital Universitario de Bellvitge, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain
1 shared publication - Nuria Lloberas
Nephrology Department, Hospital Universitari de Bellvitge–IDIBELL, Barcelona, Spain
1 shared publication
Latest Publications
- Open Access
- 11 April 2022
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 23 (8) , 4208
The Role of Inflammasomes in Glomerulonephritis
The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies.
- 11 April 2022
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 23 (8) , 4208
Open AccessThe Role of Inflammasomes in Glomerulonephritis
The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies.