Zeba N. Siddiqui

A sustainable, multicomponent strategy has been developed for the efficient synthesis of structurally diverse pseudonatural products (pNPs). Using acetic acid as a catalyst, we have synthesized three distinct pNP families: indeno-pyrrolido-pyrimidino-benzimidazole (IPPBi), indeno-pyrrolido-pyrimidino-triazoles (IPPTa), and indeno-pyrrolido-pyrimidino-tetrazoles (IPPTt). The mechanism involved the formation of acetyl indenopyrrole as a key intermediate, which enables the divergent product formation. Interestingly, the reaction proceeded efficiently under microwave irradiation (MW), resulting in an enhanced overall reaction efficiency. Broad substrate scope, operational simplicity, excellent yields, and column chromatography-free purification are advantageous features of this methodology.

A bifunctional catalyst, PTA@PC-COF, integrating Brønsted acidic and Lewis basic sites within a nitrogen-rich porous triazine framework, was engineered for sustainable one-pot multicomponent synthesis of bioactive spiro-quinazolinones.

This study explores pyridine‐based azachalcones as potential anti‐breast cancer agents. Synthesized via piperidine‐catalyzed Claisen–Schmidt condensation, these compounds exhibited high yields and significant in vitro activity against MDA‐MB‐231 and MCF‐7 cell lines, with minimal toxicity toward normal cells. Compound 3b demonstrated the most potent effect (IC ₅₀ = 9.96 µM against MDA‐MB‐231), surpassing tamoxifen. In silico studies revealed strong binding affinities to VEGFR‐2 and EGFR, supported by molecular dynamics simulations indicating stable interactions and favorable MMGBSA binding energies. ADMET profiling predicted good drug‐likeness and safety. These findings position azachalcones as potential lead scaffolds for breast cancer therapy and provide a strong foundation for future preclinical investigations.

Herein, we report the synthesis of a recyclable, mesoporous heterogeneous catalyst (MFP@IL) by functionalizing an ammonium‐cation‐based ionic liquid onto a melamine‐paraformaldehyde covalent organic polymer. The catalytic performance of MFP@IL was evaluated by synthesizing a library of pyranopyrazoles and pyranocoumarins via a one‐pot, multicomponent reaction under sustainable reaction conditions. The reactions were performed at room temperature (RT) in an aqueous medium. MFP@IL displayed excellent catalytic efficacy, high thermochemical stability, and high reusability for up to eight catalytic cycles. MFP@IL was extensively characterized by various spectroscopic techniques, such as Energy Dispersive X‐ray (EDX), Brunauer–Emmett–Teller (BET), Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), and Thermal Gravimetric (TG) analyses. The high efficiency of the protocol was demonstrated by its broad compatibility with various aldehydes and the ability to achieve excellent yields (88%–95%) within a short reaction time (15–22 min). A simple workup procedure, high purity of the title compounds, easy catalyst recovery, and use of water as a green solvent are other notable features of this methodology.

Sustainable synthesis of highly substituted pyran derivatives using Schleichera oleosa leaf derived biochar functionalized with polyaniline (PANI@ALB) as an acid–base heterogeneous catalyst under ambient conditions.

This study explores new anti‐inflammatory agents by synthesizing pyrazoline‐pyridine hybrids with N‐butylsulfonated covalent organic framework (COF‐SO₃H) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to a multi‐gram scale, highlighting its robustness and efficiency, and it operates without the need for column chromatography. Among the synthesized hybrids, compound 5d, a pyrazoline‐pyridine hybrid bearing an indole moiety, emerged as a potent anti‐inflammatory and antioxidant agent. It effectively inhibited PDE4B activation with an IC₅₀ value of 99.38 nM, without adversely affecting HEK cells. Compound 5d demonstrated its dual activity by significantly reducing ROS production and restoring mitochondrial health in LPS‐stimulated A549 and HEK cells, while also downregulating IL‐1β and NF‐ĸB/p65 expression in LPS‐stimulated A549 cells. In silico studies confirmed compound 5d’s strong binding to PDE4B, with stable RMSD and RMSF values, indicating its potential as a stable and effective PDE4B inhibitor. The compound exhibited favorable physicochemical properties, met drug‐likeness criteria, and showed low toxicity as predicted in silico. These findings suggest that compound 5d has significant potential as a therapeutic agent for inflammatory diseases due to its dual anti‐inflammatory and antioxidant activities.

Herein, we report a green, sustainable, and metal‐free, one‐pot three‐component protocol for the synthesis of indeno [1, 2‐b] quinoxalin‐11‐ylidenamine derivatives using a novel, effective, and recyclable mesoporous heterogeneous organocatalyst [MTP−IL]. [MTP−IL] was constructed by immobilizing an imidazolium‐cation‐based ionic liquid on a melamine−terephthalaldehyde covalent organic polymer and was thoroughly characterized using several analytical techniques. It displayed high thermochemical stability and catalytic efficacy, offering title compounds with 90–94 % yields in a short reaction time, and was recyclable for up to six cycles. The synthesized compounds were characterized through FTIR, ¹ H, and ¹³ C Nuclear Magnetic Resonance (NMR), and the molecular structure of N′‐(11H‐indeno[1,2‐b]quinoxalin‐11‐ylidene)benzohydrazide (7) was confirmed by the Single Crystal XRD (SCXRD) analysis. The key features of the present protocol are the use of ethanol as a green solvent, easy catalyst recovery, a simple work‐up procedure, and zero involvement of any metal.