Lang Pan
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Lang Pan has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Hewei Ming
School of Basic Medicine, Central South University, Changsha 410078, China
1 shared publication - Jiahui Zhu
School of Basic Medicine, Central South University, Changsha 410000, China
1 shared publication - Lexin Liu
School of Basic Medicine, Central South University, Changsha 410000, China
1 shared publication - Xiaodi Ma
School of Basic Medicine, Central South University, Changsha 410000, China
1 shared publication - Yang Xiang
School of Basic Medicine, Central South University, Changsha 410078, China
1 shared publication - Yu Chen
Department of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410000, China
1 shared publication
Latest Publications
- Open Access
- 9 May 2022
- Published by MDPI AG in Antioxidants
- Vol. 11 (5) , 933
OGG1 in Lung—More than Base Excision Repair
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases. The breakdown of oxidants/antioxidants system happens when the overproduction of free radicals results in an excess over the limitation of cleaning capability, which could lead to the oxidative modification of macromolecules including nucleic acids. The most common type of oxidative base, 8-oxoG, is considered the marker of DNA oxidative damage. The appearance of 8-oxoG could lead to base mismatch and its accumulation might end up as tumorigenesis. The base 8-oxoG was corrected by base excision repair initiated by 8-oxoguanine DNA glycosylase-1 (OGG1), which recognizes 8-oxoG from the genome and excises it from the DNA double strand, generating an AP site for further processing. Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease. This review intends to make an overall summary of the mechanism through which OGG1 regulates gene expression and the role of OGG1 in pulmonary diseases.
- 9 May 2022
- Published by MDPI AG in Antioxidants
- Vol. 11 (5) , 933
Open AccessOGG1 in Lung—More than Base Excision Repair
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases. The breakdown of oxidants/antioxidants system happens when the overproduction of free radicals results in an excess over the limitation of cleaning capability, which could lead to the oxidative modification of macromolecules including nucleic acids. The most common type of oxidative base, 8-oxoG, is considered the marker of DNA oxidative damage. The appearance of 8-oxoG could lead to base mismatch and its accumulation might end up as tumorigenesis. The base 8-oxoG was corrected by base excision repair initiated by 8-oxoguanine DNA glycosylase-1 (OGG1), which recognizes 8-oxoG from the genome and excises it from the DNA double strand, generating an AP site for further processing. Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease. This review intends to make an overall summary of the mechanism through which OGG1 regulates gene expression and the role of OGG1 in pulmonary diseases.