Jason Curtis

Background/Objectives: Sports supplements have become popular among fitness enthusiasts for enhancing the adaptive response to exercise. This review analyzes five of the most effective ergogenic aids: creatine, beta-alanine, nitrates, caffeine, and protein. Methods: We conducted a narrative review of the literature with a focus on the sport supplements with the most robust evidence for efficacy and safety. Results: Creatine, one of the most studied ergogenic aids, increases phosphocreatine stores in skeletal muscles, improving ATP production during high-intensity exercises like sprinting and weightlifting. Studies show creatine supplementation enhances skeletal muscle mass, strength/power, and muscular endurance. The typical dosage is 3–5 g per day and is safe for long-term use. Beta-alanine, when combined with the amino acid histidine, elevates intramuscular carnosine, which acts as a buffer in skeletal muscles and delays fatigue during high-intensity exercise by neutralizing hydrogen ions. Individuals usually take 2–6 g daily in divided doses to minimize paresthesia. Research shows significant performance improvements in activities lasting 1–4 min. Nitrates, found in beetroot juice, enhance aerobic performance by increasing oxygen delivery to muscles, enhancing endurance, and reducing oxygen cost during exercise. The recommended dosage is approximately 500 milligrams taken 2–3 h before exercise. Caffeine, a central nervous system stimulant, reduces perceived pain while enhancing focus and alertness. Effective doses range from 3 to 6 milligrams per kilogram of body weight, typically consumed an hour before exercise. Protein supplementation supports muscle repair, growth, and recovery, especially after resistance training. The recommended intake for exercise-trained men and women varies depending on their specific goals. Concluions: In summary, creatine, beta-alanine, nitrates, caffeine, and protein are the best ergogenic aids, with strong evidence supporting their efficacy and safety.

Background: It has been suggested that supplementation with Tongkat Ali may affect testosterone concentrations; moreover, whether this influences body composition is unclear. Thus, the purpose of this investigation was to determine if four weeks of Tongkat Ali (400 mg daily dose) supplementation affected body composition and salivary free testosterone concentrations. Methods: Thirty-three exercise-trained males (n = 19) and females (n = 14) volunteered for this investigation (mean ± standard deviation: age 33.1 ± 13.0 years; height 171.1 ± 11.3 cm; body mass 77.4 ± 16.8 kg; average total years of training 13.9 ± 13.2; average hours of resistance training/week 4.2 ± 2.5; average hours of aerobic exercise/week 3.4 ± 2.8; average hours of other exercise/week 1.1 ± 2.0). Research participants were pre- and post-tested for body composition (InBody 270), Profile of Mood States (POMS), handgrip strength, and sleep (Pittsburgh Sleep Quality Index [PSQI]). In a subset of the research participants, saliva samples were collected and analyzed for cortisol and free testosterone. The research participants consumed 400 mg of Tongkat Ali or a placebo (rice flour) daily for four weeks. Results: There were no between-group differences (p > 0.05) for body composition (delta score, mean ± SD: lean body mass kg-treatment −0.5 ± 1.9, placebo −0.4 ± 0.7; fat mass kg-treatment −0.5 ± 1.6, placebo 0.3 ± 1.0, % fat treatment −0.1 ± 1.4, placebo 0.5 ± 1.1). Moreover, there were no differences between groups for any additional assessments (e.g., handgrip strength, mood, sleep, and salivary free testosterone and cortisol). Conclusions: Four weeks of supplementation with Tongkat Ali in exercise-trained males and females does not affect body composition, mood, sleep, vigilant attention, handgrip strength, cortisol, and free testosterone.

Objective The purpose of this study was to investigate the effects of a multi-ingredient pre-workout supplement (MIPS) on mental and physical performance. Materials and methods Fourteen exercise-trained men (n=7) and women (n=7) completed this randomized, placebo-controlled, double-blind, counterbalanced, crossover trial. Participants consumed either a MIPS or a placebo in a randomized, counterbalanced order. Forty-five minutes after consumption, the following assessments were conducted: psychomotor vigilance test (PVT), Profile of Mood States (POMS), vertical jump test, and heart rate and blood pressure. There was a one-week washout period between assessments. Results Statistically significant differences were observed between the treatment and placebo groups for the PVT (reaction time: treatment: 286 ± 28 ms, placebo: 306 ± 46 ms, p=0.0371) and POMS (i.e., vigor: treatment: 15.2 ± 14.9, placebo: 9.7 ± 9.6, p=0.0403; fatigue: treatment: 1.0 ± 1.1, placebo: 3.3 ± 3.4, p=0.0100). There were no significant differences between groups for the other indices of mood, false starts from the PVT, and vertical jump. Conclusion Based on our findings, the acute consumption of a MIPS produced a significant improvement in a sustained-attention, reaction-timed task as well as measures of vigor and fatigue.

Numerous gene variants are linked to an individual’s propensity to become overweight or obese. The most commonly studied gene variant is the FTO single nucleotide polymorphism. The FTO risk allele is linked with increased body mass, BMI and other lifestyle factors that may perpetuate an individual’s risk for obesity. Studies assessing eating behaviors, eating preferences, nutrition interventions and other lifestyle factors were reviewed. These studies demonstrated a clear difference in eating behaviors and preferences. Lifestyle modifications including physical activity and diet were effective in weight management even in those with the risk allele.

The purpose of this study was to investigate the effects of a multi-ingredient pre-workout supplement (MIPS) on mental and physical performance. Fourteen exercise-trained men (n=7) and women (n=7) completed this randomized, placebo-controlled, double-blind, counterbalanced, crossover trial. Participants consumed either a MIPS or a placebo in a randomized, counterbalanced order. Forty-five minutes after consumption, the following assessments were conducted: psychomotor vigilance test (PVT), Profile of Mood States (POMS), vertical jump test, and heart rate and blood pressure. There was a one-week washout period between assessments. Statistically significant differences were observed between the treatment and placebo groups for the PVT (reaction time: treatment: 286 ± 28 ms, placebo: 306 ± 46 ms, p=0.0371) and POMS (i.e., vigor: treatment: 15.2 ± 14.9, placebo: 9.7 ± 9.6, p=0.0403; fatigue: treatment: 1.0 ± 1.1, placebo: 3.3 ± 3.4, p=0.0100). There were no significant differences between groups for the other indices of mood, false starts from the PVT, and vertical jump. Based on our findings, the acute consumption of a MIPS produced a significant improvement in a sustained-attention, reaction-timed task as well as measures of vigor and fatigue.