Lei Song

This corrects the article Allicin Alleviates Aortic Dissection Progression via p38/MAPK/NF-κB Signaling Pathways. Dear Readers, Following the publication of the above-mentioned article, an error was identified in the authors' names (1). In the published version, the authors' names were incorrectly listed as "Wuyi wu Ban" and "Liying wu Qiu." The correct author names are as follows:-Wuyi Ban-Liying Qiu These corrections pertain only to the authorship information and do not affect the scientific content, results, or conclusions of the article.

Purpose Aortic dissection (AD) represents a critical medical condition characterized by a high mortality rate and limited therapeutic options. The pathogenesis of AD is associated with the extracellular matrix degradation, phenotypic switching and the loss of vascular smooth muscle cells (VSMCs). Berberine (BBR) has demonstrated promising protective effects in various cardiovascular diseases, but its impact on AD and the underlying mechanisms remains unexplored. This study aims to investigate the potential of BBR in reducing the development of AD and preventing the phenotypic transformation of VSMCs, thereby proposing a novel therapeutic strategy for this life-threatening condition. Methods C57BL/6J mice and isolated VSMCs were used as in vivo and in vitro models, respectively. An AD mouse model was established through intragastric administration of β-aminopropionitrile monofumarate (BAPN), and VSMC phenotypic transformation was induced by angiotensin II (Ang-II) to assess the preventative effects of BBR. Results BBR significantly mitigates AD in a BAPN-induced mouse model by reducing AD incidence from 80–45% and increasing survival rates from 50–70%. BBR treatment alleviates aortic dilation and improves aortic morphology, while also attenuating extracellular matrix degradation, as evidenced by reduced collagen type I and fibronectin degradation. Histological and immunohistochemical analyses reveal that BBR diminishes inflammation, as indicated by reduced IL-6 and HIF-1α expression, and mitigates oxidative stress by lowering MDA levels and enhancing SOD activity. Additionally, BBR counteracts VSMC phenotypic transformation and apoptosis, demonstrated by restored contractile protein levels and reduced caspase-3, AKT, and PI3K levels. It also inhibits VSMC proliferation, migration, and MMP expression in vitro, highlighting its protective role against AD progression. Conclusion BBR exhibits protective effects against BAPN-induced AD in C57BL/6J mice, highlighting its potential as a viable and innovative therapeutic option for preventing AD progression.

Organic fluorides are widely used in pharmaceuticals, agrochemicals, material sciences, and other fields due to the special physical and chemical properties of fluorine atoms. The synthesis of alkyl fluorinated compounds bearing multiple contiguous stereogenic centers is the most challenging research area in synthetic chemistry and has received extensive attention from chemists. This review summarized the important research progress in the field over the past decade, including asymmetric electrophilic fluorination and the asymmetric elaboration of fluorinated substrates (such as allylic alkylation reactions, hydrofunctionalization reactions, Mannich addition reactions, Michael addition reactions, aldol addition reactions, and miscellaneous reactions), with an emphasis on synthetic methodologies, substrate scopes, and reaction mechanisms.

Poly (vinyl alcohol)/β-cyclodextrin (PVA/CD) composite fibers are prepared by wet spinning followed by hot stretching. XRD results show that β-CDs are in an amorphous state in fiber, and β-CD can help maintain the fibrous crystal that exists in the composite fiber. The DSC results show that the total crystalline ratio of the composite fibers decreased with the increase of β-CD. The as-prepared composite fibers were further crosslinked with glutaraldehyde (GA) to improve their usability. The crosslinked structure, together with amorphous β-CD, contributes to the loading and sustained release of fragrance molecules that were studied. The fragrance retention ratio of PVA/CD/GA is 55.63% and 48.25% for cis-jasmone and citronella, even after 25 days. The inclusion complexes of β-CD and fragrance molecules are confirmed by 2D-FTIR, which is responsible for the sustained release of fragrance. This study may contribute to the mass production of wearable long-term scented fabrics.