Pengrui Dang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Pengrui Dang has a total of 22 co-authors. Here are the top co-authors by number of shared publications:
Chenguang Zhang
Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510275, Guangdong, Peoples R China
2 shared publicationsJiechen Wang
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, Wuhan 430022, Peoples R China
2 shared publicationsLu Wang
Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510275, Guangdong, Peoples R China
2 shared publications- Biyao Wang
The VIP Department, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, Shenyang, China
1 shared publication - Feilong Deng
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, PR China
1 shared publication Huimin Zheng
Peking Univ Sch & Hosp Stomatol, Dept Geriatr Dent, NMPA Key Lab Dent Mat Natl Engn Lab Digital & Mat, Beijing 100081, Peoples R China
1 shared publication
Latest Publications
- Open Access
- 20 March 2023
- Published by Wiley in Cell Proliferation
- Vol. 56 (10) , e13443
Hollow mesoporous organosilica nanoparticles reduced graphene oxide based nanosystem for multimodal image‐guided photothermal/photodynamic/chemo combinational therapy triggered by near‐infrared
Developing a nanosystem that can perform multimodal imaging‐guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide‐grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of reactive oxygen species (ROS). When locally injected, the HMONs‐rNGO@Fe3O4/MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near‐infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging‐guided combination therapy for cancer.
- 20 March 2023
- Published by Wiley in Cell Proliferation
- Vol. 56 (10) , e13443
Open AccessHollow mesoporous organosilica nanoparticles reduced graphene oxide based nanosystem for multimodal image‐guided photothermal/photodynamic/chemo combinational therapy triggered by near‐infrared
Developing a nanosystem that can perform multimodal imaging‐guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide‐grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of reactive oxygen species (ROS). When locally injected, the HMONs‐rNGO@Fe3O4/MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near‐infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging‐guided combination therapy for cancer.
- Top Cited PapersOpen Access
PEEK in Fixed Dental Prostheses: Application and Adhesion Improvement
Polyetheretherketone (PEEK) has been widely applied in fixed dental prostheses, comprising crowns, fixed partial dentures, and post-and-core. PEEK’s excellent mechanical properties facilitate better stress distribution than conventional materials, protecting the abutment teeth. However, the stiffness of PEEK is not sufficient, which can be improved via fiber reinforcement. PEEK is biocompatible. It is nonmutagenic, noncytotoxic, and nonallergenic. However, the chemical stability of PEEK is a double-edged sword. On the one hand, PEEK is nondegradable and intraoral corrosion is minimized. On the other hand, the inert surface makes adhesive bonding difficult. Numerous strategies for improving the adhesive properties of PEEK have been explored, including acid etching, plasma treatment, airborne particle abrasion, laser treatment, and adhesive systems.
Top Cited PapersOpen AccessPEEK in Fixed Dental Prostheses: Application and Adhesion Improvement
Polyetheretherketone (PEEK) has been widely applied in fixed dental prostheses, comprising crowns, fixed partial dentures, and post-and-core. PEEK’s excellent mechanical properties facilitate better stress distribution than conventional materials, protecting the abutment teeth. However, the stiffness of PEEK is not sufficient, which can be improved via fiber reinforcement. PEEK is biocompatible. It is nonmutagenic, noncytotoxic, and nonallergenic. However, the chemical stability of PEEK is a double-edged sword. On the one hand, PEEK is nondegradable and intraoral corrosion is minimized. On the other hand, the inert surface makes adhesive bonding difficult. Numerous strategies for improving the adhesive properties of PEEK have been explored, including acid etching, plasma treatment, airborne particle abrasion, laser treatment, and adhesive systems.