Te-Nien Chien
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Te-Nien Chien has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Chengcheng Li
College of Management, National Taipei University of Technology, Taipei 106, Taiwan
5 shared publications - Chih-Chou Chiu
Department of Business Management, National Taipei University of Technology, Taipei 106, Taiwan
4 shared publications - Chung-Min Wu
Department of Business Management, National Taipei University of Technology, Taipei 106, Taiwan
4 shared publications - Ling-Jing Kao
Department of Business Management, National Taipei University of Technology, Taipei 106, Taiwan
4 shared publications - Chin-Chiu Lee
College of Management, National Taipei University of Technology, Taipei 106, Taiwan
2 shared publications - Chuan-Mei Chu
College of Management, National Taipei University of Technology, Taipei 106, Taiwan
2 shared publications
Latest Publications
- Open Access
- 16 June 2026
- Published by MDPI AG in Sustainability
- Vol. 18 (12) , 6206
Machine Learning-Based Classification and Feature Analysis of Heterogeneous Environmental Sustainability Disclosure
Environmental sustainability disclosure has become increasingly critical as climate risks intensify and regulatory and investor demands for transparent, decision-useful information continue to grow. It plays a key role in reducing information asymmetry and supporting capital allocation, risk assessment, and regulatory oversight. However, prior studies predominantly rely on aggregated ESG indicators and linear models, which often fail to capture the structural heterogeneity and nonlinear relationships inherent in environmental data. This study develops a machine learning-based analytical framework to examine environmental disclosure using corporate data from the Taiwan Economic Journal (TEJ) from 2022 to 2024. A polarized sampling design is employed by selecting firms in the top and bottom 20% of ESG performance to identify and compare the distinctive disclosure characteristics of companies with high versus low environmental performance. Five models are evaluated using Accuracy, Precision, Recall, F1-score, and AUROC. The results show that ensemble models outperform traditional approaches, with CatBoost achieving the most robust performance. Feature importance analysis reveals a concentrated structure dominated by carbon emissions, energy efficiency, and waste management, while the importance of renewable energy variables increases over time. These findings highlight the nonlinear and multidimensional nature of environmental disclosure and demonstrate the value of machine learning in enhancing environmental sustainability analysis, investment decision-making, and regulatory effectiveness. As this study is based on a single-country dataset (Taiwan), future research may incorporate cross-country datasets to improve external validity.
- 16 June 2026
- Published by MDPI AG in Sustainability
- Vol. 18 (12) , 6206
Open AccessMachine Learning-Based Classification and Feature Analysis of Heterogeneous Environmental Sustainability Disclosure
Environmental sustainability disclosure has become increasingly critical as climate risks intensify and regulatory and investor demands for transparent, decision-useful information continue to grow. It plays a key role in reducing information asymmetry and supporting capital allocation, risk assessment, and regulatory oversight. However, prior studies predominantly rely on aggregated ESG indicators and linear models, which often fail to capture the structural heterogeneity and nonlinear relationships inherent in environmental data. This study develops a machine learning-based analytical framework to examine environmental disclosure using corporate data from the Taiwan Economic Journal (TEJ) from 2022 to 2024. A polarized sampling design is employed by selecting firms in the top and bottom 20% of ESG performance to identify and compare the distinctive disclosure characteristics of companies with high versus low environmental performance. Five models are evaluated using Accuracy, Precision, Recall, F1-score, and AUROC. The results show that ensemble models outperform traditional approaches, with CatBoost achieving the most robust performance. Feature importance analysis reveals a concentrated structure dominated by carbon emissions, energy efficiency, and waste management, while the importance of renewable energy variables increases over time. These findings highlight the nonlinear and multidimensional nature of environmental disclosure and demonstrate the value of machine learning in enhancing environmental sustainability analysis, investment decision-making, and regulatory effectiveness. As this study is based on a single-country dataset (Taiwan), future research may incorporate cross-country datasets to improve external validity.
- Open Access
- 3 July 2025
- Published by MDPI AG in Sustainability
- Vol. 17 (13) , 6091
Applying Smart Healthcare and ESG Concepts to Optimize Elderly Health Management
As the aging population grows, ensuring effective and sustainable health management for elderly individuals has become a critical challenge. This study explores the integration of smart healthcare technologies and ESG (Environmental, Social, and Governance) principles to enhance elderly health management through data-driven strategies. Using the MIMIC-III database, this study evaluates five machine learning models (Adaboost, Bagging, Catboost, GaussianNB, and SVC) through ten-fold cross-validation to predict 3-day and 30-day mortality rates among elderly ICU patients. The Bagging model achieved the best performance with an AUROC of 0.80, demonstrating the potential of smart healthcare in mortality prediction. These technologies enhance predictive accuracy, enabling the timely identification of high-risk patients and effective intervention. Through the application of smart data integration methods, this study demonstrates how combining clinical indicators with socioeconomic factors can improve healthcare equity and efficiency. Furthermore, by aligning smart healthcare development with ESG concepts, we emphasize the importance of sustainability, social responsibility, and governance transparency in future healthcare systems. The findings offer valuable contributions toward building an interoperable and ethical health ecosystem, supporting early risk identification, improved care outcomes, and the promotion of healthy living for the elderly population.
- 3 July 2025
- Published by MDPI AG in Sustainability
- Vol. 17 (13) , 6091
Open AccessApplying Smart Healthcare and ESG Concepts to Optimize Elderly Health Management
As the aging population grows, ensuring effective and sustainable health management for elderly individuals has become a critical challenge. This study explores the integration of smart healthcare technologies and ESG (Environmental, Social, and Governance) principles to enhance elderly health management through data-driven strategies. Using the MIMIC-III database, this study evaluates five machine learning models (Adaboost, Bagging, Catboost, GaussianNB, and SVC) through ten-fold cross-validation to predict 3-day and 30-day mortality rates among elderly ICU patients. The Bagging model achieved the best performance with an AUROC of 0.80, demonstrating the potential of smart healthcare in mortality prediction. These technologies enhance predictive accuracy, enabling the timely identification of high-risk patients and effective intervention. Through the application of smart data integration methods, this study demonstrates how combining clinical indicators with socioeconomic factors can improve healthcare equity and efficiency. Furthermore, by aligning smart healthcare development with ESG concepts, we emphasize the importance of sustainability, social responsibility, and governance transparency in future healthcare systems. The findings offer valuable contributions toward building an interoperable and ethical health ecosystem, supporting early risk identification, improved care outcomes, and the promotion of healthy living for the elderly population.
- Open Access
- 19 September 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (18) , 8443
Machine Learning-Based Predictions of Mortality and Readmission in Type 2 Diabetes Patients in the ICU
Prognostic outcomes for patients with type 2 diabetes in the intensive care unit (ICU), including mortality and readmission rates, are critical for informed clinical decision-making. Although existing research has established a link between type 2 diabetes and adverse outcomes in the ICU, the potential of machine learning techniques for enhancing predictive accuracy has not been fully realized. This study seeks to develop and validate predictive models employing machine learning algorithms to forecast mortality and 30-day post-discharge readmission rates among ICU type 2 diabetes patients, thereby enhancing predictive accuracy and supporting clinical decision-making. Data were extracted and preprocessed from the MIMIC-III database, focusing on 14,222 patients with type 2 diabetes and their corresponding ICU admission records. Comprehensive information, including vital signs, laboratory results, and demographic characteristics, was utilized. Six machine learning algorithms—bagging, AdaBoost, GaussianNB, logistic regression, MLP, and SVC—were developed and evaluated using 10-fold cross-validation to predict mortality at 3 days, 30 days, and 365 days, as well as 30-day post-discharge readmission rates. The machine learning models demonstrated strong predictive performance for both mortality and readmission rates. Notably, the bagging and AdaBoost models showed superior performance in predicting mortality across various time intervals, achieving AUC values up to 0.8112 and an accuracy of 0.8832. In predicting 30-day readmission rates, the MLP and AdaBoost models yielded the highest performance, with AUC values reaching 0.8487 and accuracy rates of 0.9249. The integration of electronic health record data with advanced machine learning techniques significantly enhances the accuracy of mortality and readmission predictions in ICU type 2 diabetes patients. These models facilitate the identification of high-risk patients, enabling timely interventions, improving patient outcomes, and demonstrating the significant potential of machine learning in clinical prediction and decision support.
- 19 September 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (18) , 8443
Open AccessMachine Learning-Based Predictions of Mortality and Readmission in Type 2 Diabetes Patients in the ICU
Prognostic outcomes for patients with type 2 diabetes in the intensive care unit (ICU), including mortality and readmission rates, are critical for informed clinical decision-making. Although existing research has established a link between type 2 diabetes and adverse outcomes in the ICU, the potential of machine learning techniques for enhancing predictive accuracy has not been fully realized. This study seeks to develop and validate predictive models employing machine learning algorithms to forecast mortality and 30-day post-discharge readmission rates among ICU type 2 diabetes patients, thereby enhancing predictive accuracy and supporting clinical decision-making. Data were extracted and preprocessed from the MIMIC-III database, focusing on 14,222 patients with type 2 diabetes and their corresponding ICU admission records. Comprehensive information, including vital signs, laboratory results, and demographic characteristics, was utilized. Six machine learning algorithms—bagging, AdaBoost, GaussianNB, logistic regression, MLP, and SVC—were developed and evaluated using 10-fold cross-validation to predict mortality at 3 days, 30 days, and 365 days, as well as 30-day post-discharge readmission rates. The machine learning models demonstrated strong predictive performance for both mortality and readmission rates. Notably, the bagging and AdaBoost models showed superior performance in predicting mortality across various time intervals, achieving AUC values up to 0.8112 and an accuracy of 0.8832. In predicting 30-day readmission rates, the MLP and AdaBoost models yielded the highest performance, with AUC values reaching 0.8487 and accuracy rates of 0.9249. The integration of electronic health record data with advanced machine learning techniques significantly enhances the accuracy of mortality and readmission predictions in ICU type 2 diabetes patients. These models facilitate the identification of high-risk patients, enabling timely interventions, improving patient outcomes, and demonstrating the significant potential of machine learning in clinical prediction and decision support.
- Open Access
- 18 September 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (18) , 5503
Predicting ICU Readmission from Electronic Health Records via BERTopic with Long Short Term Memory Network Approach
Background: The increasing rate of intensive care unit (ICU) readmissions poses significant challenges in healthcare, impacting both costs and patient outcomes. Predicting patient readmission after discharge is crucial for improving medical quality and reducing expenses. Traditional analyses of electronic health record (EHR) data have primarily focused on numerical data, often neglecting valuable text data. Methods: This study employs a hybrid model combining BERTopic and Long Short-Term Memory (LSTM) networks to predict ICU readmissions. Leveraging the MIMIC-III database, we utilize both quantitative and text data to enhance predictive capabilities. Our approach integrates the strengths of unsupervised topic modeling with supervised deep learning, extracting potential topics from patient records and transforming discharge summaries into topic vectors for more interpretable and personalized predictions. Results: Utilizing a comprehensive dataset of 36,232 ICU patient records, our model achieved an AUROC score of 0.80, thereby surpassing the performance of traditional machine learning models. The implementation of BERTopic facilitated effective utilization of unstructured data, generating themes that effectively guide the selection of relevant predictive factors for patient readmission prognosis. This significantly enhanced the model’s interpretative accuracy and predictive capability. Additionally, the integration of importance ranking methods into our machine learning framework allowed for an in-depth analysis of the significance of various variables. This approach provided crucial insights into how different input variables interact and impact predictions of patient readmission across various clinical contexts. Conclusions: The practical application of BERTopic technology in our hybrid model contributes to more efficient patient management and serves as a valuable tool for developing tailored treatment strategies and resource optimization. This study highlights the significance of integrating unstructured text data with traditional quantitative data to develop more accurate and interpretable predictive models in healthcare, emphasizing the importance of individualized care and cost-effective healthcare paradigms.
- 18 September 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (18) , 5503
Open AccessPredicting ICU Readmission from Electronic Health Records via BERTopic with Long Short Term Memory Network Approach
Background: The increasing rate of intensive care unit (ICU) readmissions poses significant challenges in healthcare, impacting both costs and patient outcomes. Predicting patient readmission after discharge is crucial for improving medical quality and reducing expenses. Traditional analyses of electronic health record (EHR) data have primarily focused on numerical data, often neglecting valuable text data. Methods: This study employs a hybrid model combining BERTopic and Long Short-Term Memory (LSTM) networks to predict ICU readmissions. Leveraging the MIMIC-III database, we utilize both quantitative and text data to enhance predictive capabilities. Our approach integrates the strengths of unsupervised topic modeling with supervised deep learning, extracting potential topics from patient records and transforming discharge summaries into topic vectors for more interpretable and personalized predictions. Results: Utilizing a comprehensive dataset of 36,232 ICU patient records, our model achieved an AUROC score of 0.80, thereby surpassing the performance of traditional machine learning models. The implementation of BERTopic facilitated effective utilization of unstructured data, generating themes that effectively guide the selection of relevant predictive factors for patient readmission prognosis. This significantly enhanced the model’s interpretative accuracy and predictive capability. Additionally, the integration of importance ranking methods into our machine learning framework allowed for an in-depth analysis of the significance of various variables. This approach provided crucial insights into how different input variables interact and impact predictions of patient readmission across various clinical contexts. Conclusions: The practical application of BERTopic technology in our hybrid model contributes to more efficient patient management and serves as a valuable tool for developing tailored treatment strategies and resource optimization. This study highlights the significance of integrating unstructured text data with traditional quantitative data to develop more accurate and interpretable predictive models in healthcare, emphasizing the importance of individualized care and cost-effective healthcare paradigms.
- Open Access
- 26 August 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (17) , 7546
Integrating Structured and Unstructured Data with BERTopic and Machine Learning: A Comprehensive Predictive Model for Mortality in ICU Heart Failure Patients
Heart failure remains a leading cause of mortality worldwide, particularly within Intensive Care Unit (ICU)-patient populations. This study introduces an innovative approach to predicting ICU mortality by seamlessly integrating electronic health record (EHR) data with a BERTopic-based hybrid machine-learning methodology. The MIMIC-III database serves as the primary data source, encompassing structured and unstructured data from 6606 ICU-admitted heart-failure patients. Unstructured data are processed using BERTopic, complemented by machine-learning algorithms for prediction and performance evaluation. The results indicate that the inclusion of unstructured data significantly enhances the model’s predictive accuracy regarding patient mortality. The amalgamation of structured and unstructured data effectively identifies key variables, enhancing the precision of the predictive model. The developed model demonstrates potential in improving healthcare decision-making, elevating patient outcomes, and optimizing resource allocation within the ICU setting. The handling and application of unstructured data emphasize the utilization of clinical narrative records by healthcare professionals, elevating this research beyond the traditional structured data predictive tools. This study contributes to the ongoing discourse in critical care and predictive modeling, offering valuable insights into the potential of integrating unstructured data into healthcare analytics.
- 26 August 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (17) , 7546
Open AccessIntegrating Structured and Unstructured Data with BERTopic and Machine Learning: A Comprehensive Predictive Model for Mortality in ICU Heart Failure Patients
Heart failure remains a leading cause of mortality worldwide, particularly within Intensive Care Unit (ICU)-patient populations. This study introduces an innovative approach to predicting ICU mortality by seamlessly integrating electronic health record (EHR) data with a BERTopic-based hybrid machine-learning methodology. The MIMIC-III database serves as the primary data source, encompassing structured and unstructured data from 6606 ICU-admitted heart-failure patients. Unstructured data are processed using BERTopic, complemented by machine-learning algorithms for prediction and performance evaluation. The results indicate that the inclusion of unstructured data significantly enhances the model’s predictive accuracy regarding patient mortality. The amalgamation of structured and unstructured data effectively identifies key variables, enhancing the precision of the predictive model. The developed model demonstrates potential in improving healthcare decision-making, elevating patient outcomes, and optimizing resource allocation within the ICU setting. The handling and application of unstructured data emphasize the utilization of clinical narrative records by healthcare professionals, elevating this research beyond the traditional structured data predictive tools. This study contributes to the ongoing discourse in critical care and predictive modeling, offering valuable insights into the potential of integrating unstructured data into healthcare analytics.
- Open Access
- 28 February 2023
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 20 (5) , 4340
Integrating Structured and Unstructured EHR Data for Predicting Mortality by Machine Learning and Latent Dirichlet Allocation Method
An ICU is a critical care unit that provides advanced medical support and continuous monitoring for patients with severe illnesses or injuries. Predicting the mortality rate of ICU patients can not only improve patient outcomes, but also optimize resource allocation. Many studies have attempted to create scoring systems and models that predict the mortality of ICU patients using large amounts of structured clinical data. However, unstructured clinical data recorded during patient admission, such as notes made by physicians, is often overlooked. This study used the MIMIC-III database to predict mortality in ICU patients. In the first part of the study, only eight structured variables were used, including the six basic vital signs, the GCS, and the patient’s age at admission. In the second part, unstructured predictor variables were extracted from the initial diagnosis made by physicians when the patients were admitted to the hospital and analyzed using Latent Dirichlet Allocation techniques. The structured and unstructured data were combined using machine learning methods to create a mortality risk prediction model for ICU patients. The results showed that combining structured and unstructured data improved the accuracy of the prediction of clinical outcomes in ICU patients over time. The model achieved an AUROC of 0.88, indicating accurate prediction of patient vital status. Additionally, the model was able to predict patient clinical outcomes over time, successfully identifying important variables. This study demonstrated that a small number of easily collectible structured variables, combined with unstructured data and analyzed using LDA topic modeling, can significantly improve the predictive performance of a mortality risk prediction model for ICU patients. These results suggest that initial clinical observations and diagnoses of ICU patients contain valuable information that can aid ICU medical and nursing staff in making important clinical decisions.
- 28 February 2023
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 20 (5) , 4340
Open AccessIntegrating Structured and Unstructured EHR Data for Predicting Mortality by Machine Learning and Latent Dirichlet Allocation Method
An ICU is a critical care unit that provides advanced medical support and continuous monitoring for patients with severe illnesses or injuries. Predicting the mortality rate of ICU patients can not only improve patient outcomes, but also optimize resource allocation. Many studies have attempted to create scoring systems and models that predict the mortality of ICU patients using large amounts of structured clinical data. However, unstructured clinical data recorded during patient admission, such as notes made by physicians, is often overlooked. This study used the MIMIC-III database to predict mortality in ICU patients. In the first part of the study, only eight structured variables were used, including the six basic vital signs, the GCS, and the patient’s age at admission. In the second part, unstructured predictor variables were extracted from the initial diagnosis made by physicians when the patients were admitted to the hospital and analyzed using Latent Dirichlet Allocation techniques. The structured and unstructured data were combined using machine learning methods to create a mortality risk prediction model for ICU patients. The results showed that combining structured and unstructured data improved the accuracy of the prediction of clinical outcomes in ICU patients over time. The model achieved an AUROC of 0.88, indicating accurate prediction of patient vital status. Additionally, the model was able to predict patient clinical outcomes over time, successfully identifying important variables. This study demonstrated that a small number of easily collectible structured variables, combined with unstructured data and analyzed using LDA topic modeling, can significantly improve the predictive performance of a mortality risk prediction model for ICU patients. These results suggest that initial clinical observations and diagnoses of ICU patients contain valuable information that can aid ICU medical and nursing staff in making important clinical decisions.
- Open Access
- 31 October 2022
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 11 (21) , 6460
Applying an Improved Stacking Ensemble Model to Predict the Mortality of ICU Patients with Heart Failure
Cardiovascular diseases have been identified as one of the top three causes of death worldwide, with onset and deaths mostly due to heart failure (HF). In ICU, where patients with HF are at increased risk of death and consume significant medical resources, early and accurate prediction of the time of death for patients at high risk of death would enable them to receive appropriate and timely medical care. The data for this study were obtained from the MIMIC-III database, where we collected vital signs and tests for 6699 HF patient during the first 24 h of their first ICU admission. In order to predict the mortality of HF patients in ICUs more precisely, an integrated stacking model is proposed and applied in this paper. In the first stage of dataset classification, the datasets were subjected to first-level classifiers using RF, SVC, KNN, LGBM, Bagging, and Adaboost. Then, the fusion of these six classifier decisions was used to construct and optimize the stacked set of second-level classifiers. The results indicate that our model obtained an accuracy of 95.25% and AUROC of 82.55% in predicting the mortality rate of HF patients, which demonstrates the outstanding capability and efficiency of our method. In addition, the results of this study also revealed that platelets, glucose, and blood urea nitrogen were the clinical features that had the greatest impact on model prediction. The results of this analysis not only improve the understanding of patients’ conditions by healthcare professionals but allow for a more optimal use of healthcare resources.
- 31 October 2022
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 11 (21) , 6460
Open AccessApplying an Improved Stacking Ensemble Model to Predict the Mortality of ICU Patients with Heart Failure
Cardiovascular diseases have been identified as one of the top three causes of death worldwide, with onset and deaths mostly due to heart failure (HF). In ICU, where patients with HF are at increased risk of death and consume significant medical resources, early and accurate prediction of the time of death for patients at high risk of death would enable them to receive appropriate and timely medical care. The data for this study were obtained from the MIMIC-III database, where we collected vital signs and tests for 6699 HF patient during the first 24 h of their first ICU admission. In order to predict the mortality of HF patients in ICUs more precisely, an integrated stacking model is proposed and applied in this paper. In the first stage of dataset classification, the datasets were subjected to first-level classifiers using RF, SVC, KNN, LGBM, Bagging, and Adaboost. Then, the fusion of these six classifier decisions was used to construct and optimize the stacked set of second-level classifiers. The results indicate that our model obtained an accuracy of 95.25% and AUROC of 82.55% in predicting the mortality rate of HF patients, which demonstrates the outstanding capability and efficiency of our method. In addition, the results of this study also revealed that platelets, glucose, and blood urea nitrogen were the clinical features that had the greatest impact on model prediction. The results of this analysis not only improve the understanding of patients’ conditions by healthcare professionals but allow for a more optimal use of healthcare resources.
- Open Access
- 11 June 2022
- Published by MDPI AG in Healthcare
- Vol. 10 (6) , 1087
Predicting the Mortality of ICU Patients by Topic Model with Machine-Learning Techniques
Predicting clinical patients’ vital signs is a leading critical issue in intensive care units (ICUs) related studies. Early prediction of the mortality of ICU patients can reduce the overall mortality and cost of complication treatment. Some studies have predicted mortality based on electronic health record (EHR) data by using machine learning models. However, the semi-structured data (i.e., patients’ diagnosis data and inspection reports) is rarely used in these models. This study utilized data from the Medical Information Mart for Intensive Care III. We used a Latent Dirichlet Allocation (LDA) model to classify text in the semi-structured data of some particular topics and established and compared the classification and regression trees (CART), logistic regression (LR), multivariate adaptive regression splines (MARS), random forest (RF), and gradient boosting (GB). A total of 46,520 ICU Patients were included, with 11.5% mortality in the Medical Information Mart for Intensive Care III group. Our results revealed that the semi-structured data (diagnosis data and inspection reports) of ICU patients contain useful information that can assist clinical doctors in making critical clinical decisions. In addition, in our comparison of five machine learning models (CART, LR, MARS, RF, and GB), the GB model showed the best performance with the highest area under the receiver operating characteristic curve (AUROC) (0.9280), specificity (93.16%), and sensitivity (83.25%). The RF, LR, and MARS models showed better performance (AUROC are 0.9096, 0.8987, and 0.8935, respectively) than the CART (0.8511). The GB model showed better performance than other machine learning models (CART, LR, MARS, and RF) in predicting the mortality of patients in the intensive care unit. The analysis results could be used to develop a clinically useful decision support system.
- 11 June 2022
- Published by MDPI AG in Healthcare
- Vol. 10 (6) , 1087
Open AccessPredicting the Mortality of ICU Patients by Topic Model with Machine-Learning Techniques
Predicting clinical patients’ vital signs is a leading critical issue in intensive care units (ICUs) related studies. Early prediction of the mortality of ICU patients can reduce the overall mortality and cost of complication treatment. Some studies have predicted mortality based on electronic health record (EHR) data by using machine learning models. However, the semi-structured data (i.e., patients’ diagnosis data and inspection reports) is rarely used in these models. This study utilized data from the Medical Information Mart for Intensive Care III. We used a Latent Dirichlet Allocation (LDA) model to classify text in the semi-structured data of some particular topics and established and compared the classification and regression trees (CART), logistic regression (LR), multivariate adaptive regression splines (MARS), random forest (RF), and gradient boosting (GB). A total of 46,520 ICU Patients were included, with 11.5% mortality in the Medical Information Mart for Intensive Care III group. Our results revealed that the semi-structured data (diagnosis data and inspection reports) of ICU patients contain useful information that can assist clinical doctors in making critical clinical decisions. In addition, in our comparison of five machine learning models (CART, LR, MARS, RF, and GB), the GB model showed the best performance with the highest area under the receiver operating characteristic curve (AUROC) (0.9280), specificity (93.16%), and sensitivity (83.25%). The RF, LR, and MARS models showed better performance (AUROC are 0.9096, 0.8987, and 0.8935, respectively) than the CART (0.8511). The GB model showed better performance than other machine learning models (CART, LR, MARS, and RF) in predicting the mortality of patients in the intensive care unit. The analysis results could be used to develop a clinically useful decision support system.