Miguel A. Jiménez-Beltrán
Research Subjects
Research Interests
Miguel A. Jiménez-Beltrán has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Alan J. Gómez-Calderón
Laboratorio de Medicina Regenerativa e Ingeniería de Tejidos, División de Investigación Biomédica, Centro Médico Nacional ‘20 de Noviembre’—ISSSTE. San Lorenzo 502, 3er Piso. Col. Del Valle, Del. Benito Juárez, Mexico City 03100, Mexico
1 shared publication - Daniel Santillán-Cortez
ISSSTE, Mexico
1 shared publication - Juan Antonio Suárez-Cuenca
Institute for Social Security and Services for State Workers, Mexico City, Mexico
1 shared publication - Juan Antonio Suárez-Cuenca
Department of Clinical Research, Centro Médico Nacional “20 de Noviembre”, ISSSTE, Mexico City 03229, Mexico
1 shared publication - Mario Antonio Téllez-González
Institute for Social Security and Services for State Workers, Mexico City, Mexico
1 shared publication - Paul Mondragón-Terán
Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, CICATA-Unidad Morelos, Instituto Politécnico Nacional, Xochitepec 62790, Morelos, Mexico
1 shared publication
Latest Publications
- Open Access
Electrospinning-Generated Nanofiber Scaffolds Suitable for Integration of Primary Human Circulating Endothelial Progenitor Cells
The extracellular matrix is fundamental in order to maintain normal function in many organs such as the blood vessels, heart, liver, or bones. When organs fail or experience injury, tissue engineering and regenerative medicine elicit the production of constructs resembling the native extracellular matrix, supporting organ restoration and function. In this regard, is it possible to optimize structural characteristics of nanofiber scaffolds obtained by the electrospinning technique? This study aimed to produce partially degraded collagen (gelatin) nanofiber scaffolds, using the electrospinning technique, with optimized parameters rendering different morphological characteristics of nanofibers, as well as assessing whether the resulting scaffolds are suitable to integrate primary human endothelial progenitor cells, obtained from peripheral blood with further in vitro cell expansion. After different assay conditions, the best nanofiber morphology was obtained with the following electrospinning parameters: 15 kV, 0.06 mL/h, 1000 rpm and 12 cm needle-to-collector distance, yielding an average nanofiber thickness of 333 ± 130 nm. Nanofiber scaffolds rendered through such electrospinning conditions were suitable for the integration and proliferation of human endothelial progenitor cells.
Open AccessElectrospinning-Generated Nanofiber Scaffolds Suitable for Integration of Primary Human Circulating Endothelial Progenitor Cells
The extracellular matrix is fundamental in order to maintain normal function in many organs such as the blood vessels, heart, liver, or bones. When organs fail or experience injury, tissue engineering and regenerative medicine elicit the production of constructs resembling the native extracellular matrix, supporting organ restoration and function. In this regard, is it possible to optimize structural characteristics of nanofiber scaffolds obtained by the electrospinning technique? This study aimed to produce partially degraded collagen (gelatin) nanofiber scaffolds, using the electrospinning technique, with optimized parameters rendering different morphological characteristics of nanofibers, as well as assessing whether the resulting scaffolds are suitable to integrate primary human endothelial progenitor cells, obtained from peripheral blood with further in vitro cell expansion. After different assay conditions, the best nanofiber morphology was obtained with the following electrospinning parameters: 15 kV, 0.06 mL/h, 1000 rpm and 12 cm needle-to-collector distance, yielding an average nanofiber thickness of 333 ± 130 nm. Nanofiber scaffolds rendered through such electrospinning conditions were suitable for the integration and proliferation of human endothelial progenitor cells.