Ashwin Alke Pai
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Ashwin Alke Pai has a total of 20 co-authors. Here are the top co-authors by number of shared publications:
- Quillian Young Sing
Department of Plastic Surgery, Sheffield Children’s Hospital, Sheffield, UK
2 shared publications A. Misra
1 shared publication- Aline Yen Ling Wang
Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
1 shared publication Alok Misra
Wexham Park Hospital, UK
1 shared publicationAparna Udyavar Pai
Radiology, The Hillingdon Hospitals NHS Foundation Trust, Uxbridge, UK
1 shared publication- Charles Yuen Yung Loh
Department of Plastic Surgery, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK
1 shared publication
Latest Publications
- Open Access
- 7 July 2024
- Published by Elsevier in JPRAS Open
- Vol. 43, 514-517
Autologous fat grafting for management of pain at spinal cord implantable pulse generator sites
- 7 July 2024
- Published by Elsevier in JPRAS Open
- Vol. 43, 514-517
Open AccessAutologous fat grafting for management of pain at spinal cord implantable pulse generator sites
- Open Access
- 21 February 2024
- Published by Elsevier in JPRAS Open
- Vol. 40, 305-319
Free Fibula Flap for Congenital Pseudarthrosis of the Tibia: Indications and Challenges
- 21 February 2024
- Published by Elsevier in JPRAS Open
- Vol. 40, 305-319
Open AccessFree Fibula Flap for Congenital Pseudarthrosis of the Tibia: Indications and Challenges
- Open Access
- 23 June 2022
- Published by Elsevier in JPRAS Open
- Vol. 34, 10-20
Analysis of clinical and patient-reported outcomes in post-ELAPE perineal reconstruction with IGAP flap – A 5-year review
- 23 June 2022
- Published by Elsevier in JPRAS Open
- Vol. 34, 10-20
Open AccessAnalysis of clinical and patient-reported outcomes in post-ELAPE perineal reconstruction with IGAP flap – A 5-year review
- 16 June 2022
- Published by BMJ in BMJ Case Reports
- Vol. 15 (6) , e250324
Osteomyelitis of the thumb following a trivial trauma
- 16 June 2022
- Published by BMJ in BMJ Case Reports
- Vol. 15 (6) , e250324
Osteomyelitis of the thumb following a trivial trauma
- Open Access
- 6 June 2022
- Published by MDPI AG in Pharmaceutics
- Vol. 14 (6) , 1206
Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice
(1) Background: Diabetes impairs angiogenesis and wound healing. Paracrine secretion from adipose stem cells (ASCs) contains membrane-bound nano-vesicles called exosomes (ASC-Exo) but the functional role and therapeutic potential of diabetic ASC-Exo in wound healing are unknown. This study aims to investigate the in vivo mechanistic basis by which diabetic ASC-Exo enhance cutaneous wound healing in a diabetic mouse model. (2) Methods: Topically applied exosomes could efficiently target and preferentially accumulate in wound tissue, and the cellular origin, ASC or dermal fibroblast (DFb), has no influence on the biodistribution pattern of exosomes. In vivo, full-thickness wounds in diabetic mice were treated either with ASC-Exo, DFb-Exo, or phosphate-buffered saline (PBS) topically. ASC-Exo stimulated wound healing by dermal cell proliferation, keratinocyte proliferation, and angiogenesis compared with DFb-Exo and PBS-treated wounds. (3) Results: Diabetic ASC-Exo stimulated resident monocytes/macrophages to secrete more TGF-β1 and activate the TGF-β/Smad3 signaling pathway. Fibroblasts activated by TGF-β1containing exosomes from ASCs initiate the production of TGF-β1 protein in an autocrine fashion, which leads to more proliferation and activation of fibroblasts. TGF-β1 is centrally involved in diabetic ASC-Exo mediated cellular crosstalk as an important early response to initiating wound regeneration. (4) Conclusions: The application of diabetic ASC-Exo informs the potential utility of a cell-free therapy in diabetic wound healing.
- 6 June 2022
- Published by MDPI AG in Pharmaceutics
- Vol. 14 (6) , 1206
Open AccessTherapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice
(1) Background: Diabetes impairs angiogenesis and wound healing. Paracrine secretion from adipose stem cells (ASCs) contains membrane-bound nano-vesicles called exosomes (ASC-Exo) but the functional role and therapeutic potential of diabetic ASC-Exo in wound healing are unknown. This study aims to investigate the in vivo mechanistic basis by which diabetic ASC-Exo enhance cutaneous wound healing in a diabetic mouse model. (2) Methods: Topically applied exosomes could efficiently target and preferentially accumulate in wound tissue, and the cellular origin, ASC or dermal fibroblast (DFb), has no influence on the biodistribution pattern of exosomes. In vivo, full-thickness wounds in diabetic mice were treated either with ASC-Exo, DFb-Exo, or phosphate-buffered saline (PBS) topically. ASC-Exo stimulated wound healing by dermal cell proliferation, keratinocyte proliferation, and angiogenesis compared with DFb-Exo and PBS-treated wounds. (3) Results: Diabetic ASC-Exo stimulated resident monocytes/macrophages to secrete more TGF-β1 and activate the TGF-β/Smad3 signaling pathway. Fibroblasts activated by TGF-β1containing exosomes from ASCs initiate the production of TGF-β1 protein in an autocrine fashion, which leads to more proliferation and activation of fibroblasts. TGF-β1 is centrally involved in diabetic ASC-Exo mediated cellular crosstalk as an important early response to initiating wound regeneration. (4) Conclusions: The application of diabetic ASC-Exo informs the potential utility of a cell-free therapy in diabetic wound healing.