Eric Diller
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Eric Diller has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Anna E. H. Zavodni
Department of Medicine, Division of Cardiology, Toronto, Canada, M5S 1A8
1 shared publication - John Parkinson
Department of Molecular Genetics, University of Toronto
1 shared publication - Lee-Anne Huber
Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada
1 shared publication - Mohsen Mohammadigheisar
Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada
1 shared publication - Naomi Matsuura
Department of Materials Science and Engineering, University of Toronto, Toronto, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Canada; Department of Medical Imaging, University of Toronto, Toronto, Canada
1 shared publication - Peyman Shokrollahi
Mechanical and Industrial Engineering, University of Toronto, 7938 Toronto, Ontario, Canada, M5S 3G8
1 shared publication
Latest Publications
- 9 December 2020
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE/ASME Transactions on Mechatronics
- Vol. 26 (5) , 2616-2628
Blindly Controlled Magnetically Actuated Capsule for Noninvasive Sampling of the Gastrointestinal Microbiome
Objective: To address the challenges of physical sample retrieval from all locations along patients’ gastrointestinal (GI) tracts for studying of interactions between GI microbial communities (microbiomes) and host immune systems. Methods: We propose a novel tetherless, blindly controlled, magnetically actuated capsule for noninvasive sampling of GI microbiomes and liquid digesta. The mesoscale capsule, a soft mobile robot platform, is made from two permanent magnets encapsulated in a soft elastomer and actuated remotely by an external magnet. The capsule is controlled blindly using an external magnet to orient and activate the capsule. Following oral administration, capsules transit the GI tract and are activated at specified locations. The capsule is recovered via routine stool passage and collected samples are processed for downstream analyses (e.g. 16S rRNA surveys, metagenomics, metatranscriptomics and/or metabolomics). The localization of the capsule is estimated using the travelling time and the location of collected microbiomes will be confirmed by downstream analyses. A mathematical model of capsule activation is used to predict capsule activation and guide design optimization. Results: We demonstrate the ability of the capsule to collect samples, as well as maintain sample integrity in vitro, ex vivo, and with twelve capsules in in vivo swine models. Eleven capsules successfully collected digesta (in the range of 18 to 61 mg). Conclusion: The capsule successfully collected and sealed samples. Significance: This sampling apparatus offers a technological advance for the robust sampling of GI tract contents.
- 9 December 2020
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE/ASME Transactions on Mechatronics
- Vol. 26 (5) , 2616-2628
Blindly Controlled Magnetically Actuated Capsule for Noninvasive Sampling of the Gastrointestinal Microbiome
Objective: To address the challenges of physical sample retrieval from all locations along patients’ gastrointestinal (GI) tracts for studying of interactions between GI microbial communities (microbiomes) and host immune systems. Methods: We propose a novel tetherless, blindly controlled, magnetically actuated capsule for noninvasive sampling of GI microbiomes and liquid digesta. The mesoscale capsule, a soft mobile robot platform, is made from two permanent magnets encapsulated in a soft elastomer and actuated remotely by an external magnet. The capsule is controlled blindly using an external magnet to orient and activate the capsule. Following oral administration, capsules transit the GI tract and are activated at specified locations. The capsule is recovered via routine stool passage and collected samples are processed for downstream analyses (e.g. 16S rRNA surveys, metagenomics, metatranscriptomics and/or metabolomics). The localization of the capsule is estimated using the travelling time and the location of collected microbiomes will be confirmed by downstream analyses. A mathematical model of capsule activation is used to predict capsule activation and guide design optimization. Results: We demonstrate the ability of the capsule to collect samples, as well as maintain sample integrity in vitro, ex vivo, and with twelve capsules in in vivo swine models. Eleven capsules successfully collected digesta (in the range of 18 to 61 mg). Conclusion: The capsule successfully collected and sealed samples. Significance: This sampling apparatus offers a technological advance for the robust sampling of GI tract contents.