Yueyun Xu

Chronic consumption of high-fat diets (HFDs) induces obesity and metabolic dysfunction and is accompanied by progressive skeletal muscle wasting. Although aerobic exercise is generally considered less effective for maintaining muscle mass, accumulating evidence suggests that it can attenuate HFD-induced muscle wasting. However, the molecular mechanisms underlying this protective effect remain poorly defined. In this study, we investigated the effects of moderate-intensity continuous training (MICT) on HFD-induced muscle wasting and characterized the associated transcriptomic adaptations in the mouse gastrocnemius muscle. 21 weeks of HFD feeding increased body weight and serum glucose levels and induced marked muscle wasting, as evidenced by reduced gastrocnemius muscle index, impaired forelimb grip strength, decreased muscle fiber cross-sectional area, and excessive intramuscular lipid accumulation. These pathological alterations were significantly attenuated by an 8-week MICT intervention. RNA sequencing revealed that HFD predominantly induced a lipid-centered transcriptional program characterized by enhanced fatty acid uptake, trafficking, and β-oxidation. In contrast, MICT predominantly suppressed atrophy-associated genes ( Foxo1 , Fbxo32 , and Trim63 ), while exerting minimal effects on myogenic genes ( Pax7 , Myod1 , and Myog ). Functional enrichment analyses further indicated that MICT modulated signaling pathways related to FoxO, PI3K–Akt, MAPK, and insulin signaling, together with biological processes associated with angiogenesis and calcium signaling. Collectively, these results suggest that MICT mitigates HFD-induced muscle wasting primarily by reprogramming the transcriptome from a lipotoxic, atrophic state toward a more insulin-sensitive, pro-angiogenic profile, with limited myogenic activation.

Taking Fujian Province, a typical manufacturing cluster region in China, as the case study, we constructed a dual-dimensional eco-industrial index and a dynamic coupling framework tailored for sports-manufacturing-oriented regions. By integrating multi-dimensional spatial analysis methods, we systematically revealed the synergistic mechanisms between the sports industry and the ecological environment. The research findings indicate that regional coordination exhibits a three-stage transition pattern of “scale-efficiency-resilience.” Technological investment dominates the scale expansion stage, urbanization quality drives the efficiency transformation period, and the ecological foundation supports resilience reconstruction under external shocks. Geographical barriers result in a fragmented spatial pattern between coastal and inland areas, triggering the implicit transfer of ecological burdens. Industrial chain synergy manifests as the greening of the manufacturing end, reducing the upstream ecological footprint, and functional complementarity at the service end, bridging regional disparities. The study proposes a three-dimensional governance network of “manufacturing-service-ecology,” offering a sustainable development paradigm for global manufacturing-intensive regions to promote the deep synergy between ecological civilization and industrial transformation.

The sustainable development of sports facilities and their integration with the ecological environment are crucial in addressing global environmental challenges. This study examines the coupling coordination between sports facilities and the ecological environment in nine prefecture-level cities in Fujian Province, China, from 2013 to 2020, within the framework of China’s “Dual Carbon” strategy. Using a multidisciplinary approach that integrates economics, sociology, and geography, the study employs the entropy method and coupling coordination models to analyze the temporal evolution and spatial distribution of the coupling coordination between sports facilities and the ecological environment. The findings reveal that the overall trend of coupling coordination is positive, with the degree of coordination improving over time from severe imbalance in 2013 to high-quality coordination by 2020. Economic factors, such as per capita GDP, positively influence the coupling coordination, while factors like population density and regional GDP have a negative impact. Coastal cities, such as Xiamen and Zhangzhou, demonstrate stronger regional correlations and play a critical role in improving the overall coupling level of the province. This research provides several recommendations for promoting orderly and optimal development, considering the distinct characteristics of sports facilities and the ecological environment.

Sports facilities are a crucial physical safeguard and means of sustaining sporting activities. The steady and healthy development of sports facilities can promote the sustainable development of the social economy. In order to explore the coordination status and influencing factors between sports facilities construction and the social economy, this paper built a coupling coordination evaluation index system and dynamic factor index system for the sports facilities construction and social economy development by using the entropy method, coupling coordination model and random effect model. This paper assessed the comprehensive level, coupling coordination relationship, and influencing factors of the sports facilities and social economy development of nine cities in the Fujian Province across China from 2016 to 2020. The results show the overall level of sports facilities construction in Fujian is better than the social economy development, and the two systems are interacting with each other. The level of coupling and coordination gradually changes from good coordination to quality sustainable coordination. The coupling coordinated relationship between the two systems is developing in a positive way. In addition, industrial development, the level of urban development, and environmental development as influencing factors have a clear positive effect on the degree of coupling coordination. This study provides several recommendations for cities to achieve sustainable coordinated development. This paper also may provide a direction and path for future research.

Under the restriction of ecological and environmental factors, our requirements have improved for the development path of gymnasium construction. According to the previous way to carry out the development path of gymnasium construction will make our construction work encounter a lot of unnecessary troubles, so we can improve the success rate of the development path of gymnasium construction under the constraints of the ecological environment by carrying out relevant evasive operations according to the constraints of ecological environment. The topological path and path algorithm used to improve the efficiency of stadium construction and development path under the constraints of ecological environment, TEG algorithm, Q‐TEG model, Q‐TEG algorithm, Dtra algorithm, TraD algorithm, ResR algorithm, and Q‐TED algorithm used in resource reservation plus time slot plus hosting bring the following advantages: (1) we use topological path and path algorithm to explore topological representation methods suitable for development path. The overview provides a theoretical basis for guidance, for forwarding technology scheduling mechanisms and multi‐path forwarding mechanisms to provide higher flexibility. (2) We use the TEG algorithm of resource reservation plus time slot plus trusteeship, Q‐TEG model, and Q‐TEG algorithm under multi‐model model can deal with the capacity and link of queue in each stadium construction development path well. It is more convenient to set the packet loss threshold for the propagation experiment tested in the simulation. Better help gymnasium construction and development path transmission is successful. (3) The use of the Dtra algorithm, TraD algorithm, ResR algorithm, and Q‐TED algorithm in our stadium construction development path of a good deal of the transmission link structure between each node, so that the transmission efficiency between nodes becomes higher, making our stadium construction development path operation more efficient and convenient.