Clara Pérez-Peinado
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Clara Pérez-Peinado has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Adam Carrera-Aubesart
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
1 shared publication - Daniel Sandín
Systems Biology of Infection Lab, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés 08193, Spain
1 shared publication - David Andreu
Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain
1 shared publication - Marc Torrent
Systems Biology of Infection Laboratory, Department of Biochemistry and Molecular Biology, Biosciences Faculty, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Spain
1 shared publication - Maria Angeles Jimenez
Instituto de Química Física Blas Cabrera (IQF), CSIC, Madrid, Spain
1 shared publication - Sira Defaus
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
1 shared publication
Latest Publications
- Open Access
- 29 August 2022
- Published by MDPI AG in Biomedicines
- Vol. 10 (9) , 2110
Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties
Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with remarkably longer stability in human serum than the parent Ctn. In this work, a set of topoisomers of both Ctn and Ctn[15-34], including the retro, enantio, and retroenantio versions, were synthesized and tested to investigate the structural requirements for activity. All topoisomers were as active as the cognate sequences against Gram-negative bacteria and tumor cells while slightly more toxic towards normal cells. More importantly, the enhanced serum stability of the D-amino-acid-containing versions suggests that such topoisomers must be preferentially considered as future antimicrobial and anticancer peptide leads.
- 29 August 2022
- Published by MDPI AG in Biomedicines
- Vol. 10 (9) , 2110
Open AccessExamining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties
Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with remarkably longer stability in human serum than the parent Ctn. In this work, a set of topoisomers of both Ctn and Ctn[15-34], including the retro, enantio, and retroenantio versions, were synthesized and tested to investigate the structural requirements for activity. All topoisomers were as active as the cognate sequences against Gram-negative bacteria and tumor cells while slightly more toxic towards normal cells. More importantly, the enhanced serum stability of the D-amino-acid-containing versions suggests that such topoisomers must be preferentially considered as future antimicrobial and anticancer peptide leads.