Sebastiana Pappalardo
Research Subjects
Sebastiana Pappalardo has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Angiola Forleo
Institute for Microelectronics and Microsystems (IMM), National Research Council (CNR), Lecce, Italy
1 shared publication - Carmela Marinaro
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
1 shared publication - Gennaro Lettieri
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
1 shared publication - Luigi Montano
Local Health Authority of Salerno, Salerno, Italy, Italy
1 shared publication - Marina Piscopo
Department of Biology, University of Naples Federico II, Napoli, Italy
1 shared publication - Pasquale Perrone
Department of Psychology and Health Sciences, Pegaso Telematic University, 80143 Naples, Italy
1 shared publication
Latest Publications
- Open Access
- 3 September 2022
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 19 (17) , 11023
Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study
The Valley of Sacco River (VSR) (Latium, Italy) is an area with large-scale industrial chemical production that has led over time to significant contamination of soil and groundwater with various industrial pollutants, such as organic pesticides, dioxins, organic solvents, heavy metals, and particularly, volatile organic compounds (VOCs). In the present study, we investigated the potential impact of VOCs on the spermatozoa of healthy young males living in the VSR, given the prevalent presence of several VOCs in the semen of these individuals. To accomplish this, spermiograms were conducted followed by molecular analyses to assess the content of sperm nuclear basic proteins (SNBPs) in addition to the protamine-histone ratio and DNA binding of these proteins. We found drastic alterations in the spermatozoa of these young males living in the VSR. Alterations were seen in sperm morphology, sperm motility, sperm count, and protamine/histone ratios, and included significant reductions in SNBP–DNA binding capacity. Our results provide preliminary indications of a possible correlation between the observed alterations and the presence of specific VOCs.
- 3 September 2022
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 19 (17) , 11023
Open AccessMolecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study
The Valley of Sacco River (VSR) (Latium, Italy) is an area with large-scale industrial chemical production that has led over time to significant contamination of soil and groundwater with various industrial pollutants, such as organic pesticides, dioxins, organic solvents, heavy metals, and particularly, volatile organic compounds (VOCs). In the present study, we investigated the potential impact of VOCs on the spermatozoa of healthy young males living in the VSR, given the prevalent presence of several VOCs in the semen of these individuals. To accomplish this, spermiograms were conducted followed by molecular analyses to assess the content of sperm nuclear basic proteins (SNBPs) in addition to the protamine-histone ratio and DNA binding of these proteins. We found drastic alterations in the spermatozoa of these young males living in the VSR. Alterations were seen in sperm morphology, sperm motility, sperm count, and protamine/histone ratios, and included significant reductions in SNBP–DNA binding capacity. Our results provide preliminary indications of a possible correlation between the observed alterations and the presence of specific VOCs.