Rui Han
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Rui Han has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Jing Yan
School of Stomatology, Lanzhou University, Donggang Road No. 199, Lanzhou 730020, China
1 shared publication - Li Wang
School of Stomatology, Lanzhou University, Donggang Road No. 199, Lanzhou 730020, China
1 shared publication - Min Wang
School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
1 shared publication - Xiaojing Pan
School of Stomatology, Lanzhou University, Lanzhou, China
1 shared publication - Xin Li
School of Stomatology, Lanzhou University, Donggang Road No. 199, Lanzhou 730020, China
1 shared publication - Yichen Zhang
School of Stomatology, Lanzhou University, Donggang Road No. 199, Lanzhou 730020, China
1 shared publication
Latest Publications
- Open Access
- 17 September 2022
- Published by Wiley in Evidence-Based Complementary and Alternative Medicine
- Vol. 2022, 1-13
GC/MS-Based Urine Metabolomics Study on the Ameliorative Effect of Xanthoceras sorbifolia Extract on Alzheimer’s Disease in Mice
The cause of Alzheimers disease, the most common type of dementia today, is still unclear, and in current research, there are no drugs that work relatively well. Therefore, the study for new drugs to treat Alzheimers disease is an urgent research need. Research on the improvement of Alzheimers disease with extracts of Xanthoceras sorbifolia has been increasing in recent years, but the mechanism is not fully understood. The experiments were conducted to validate the model and analyze the treatment effect through D-galactose and Aβ25–35 induced dementia model mice, using the Morris water maze, to detect the learning behavior and brain tissue section to observe the hippocampal tissue structure of mice. We performed a nontargeted metabolomic analysis of the urine obtained from different groups of mice using gas chromatography-mass spectrometry. Fourteen potential biomarkers were identified in the mices urine, outlining five metabolic pathways of interest. It was shown that the extracts of Xanthoceras sorbifolia may exert protective effects on mice in dementia models through energy metabolism, neuroinflammation, and antioxidants. This study reveals the potential pathogenesis of Alzheimers disease and the possible therapeutic mechanism of Xanthoceras sorbifolia, suggests relevant biomarkers, and provides an additional basis for the clinical application of Xanthoceras sorbifolia.
- 17 September 2022
- Published by Wiley in Evidence-Based Complementary and Alternative Medicine
- Vol. 2022, 1-13
Open AccessGC/MS-Based Urine Metabolomics Study on the Ameliorative Effect of Xanthoceras sorbifolia Extract on Alzheimer’s Disease in Mice
The cause of Alzheimers disease, the most common type of dementia today, is still unclear, and in current research, there are no drugs that work relatively well. Therefore, the study for new drugs to treat Alzheimers disease is an urgent research need. Research on the improvement of Alzheimers disease with extracts of Xanthoceras sorbifolia has been increasing in recent years, but the mechanism is not fully understood. The experiments were conducted to validate the model and analyze the treatment effect through D-galactose and Aβ25–35 induced dementia model mice, using the Morris water maze, to detect the learning behavior and brain tissue section to observe the hippocampal tissue structure of mice. We performed a nontargeted metabolomic analysis of the urine obtained from different groups of mice using gas chromatography-mass spectrometry. Fourteen potential biomarkers were identified in the mices urine, outlining five metabolic pathways of interest. It was shown that the extracts of Xanthoceras sorbifolia may exert protective effects on mice in dementia models through energy metabolism, neuroinflammation, and antioxidants. This study reveals the potential pathogenesis of Alzheimers disease and the possible therapeutic mechanism of Xanthoceras sorbifolia, suggests relevant biomarkers, and provides an additional basis for the clinical application of Xanthoceras sorbifolia.