Zhen Zhang

Background and Objective. Long noncoding RNAs (lncRNAs) have attracted increasing attention as novel biomarkers facilitating early diagnosis, prognostic predictions, and treatment of colorectal cancer (CRC). LINC01314 is aberrantly expressed in many cancers, suggesting its role in tumor development. However, its expression and underlying molecular mechanism in CRC remain to be clarified. The aim of this study was to evaluate the expression levels of LINC01314 and its potentially interacting microRNA (miRNA) miR-96 in CRC patients, as well as clinical values. Methods. A tissue microarray (TMA) containing 76 individual colorectal tumor samples and 28 adjacent normal samples was constructed, and the expression levels of LINC01314 and miR-96 were detected by fluorescence in situ hybridization. Results. The expression levels of both LINC01314 and miR-96 were upregulated in CRC tissues and were associated with vascular metastasis ( ). A significantly positive correlation was observed between LINC01314 and miR-96 expression in tumor tissues ( , ). Dominant expression of LINC01314 was a risk factor for both blood vessel invasion ( ) and poor 5-year survival ( , hazard ). The Kaplan–Meier analysis indicated that patients with LINC01314-dominant expression exhibited worse 5-year survival rates than those with miR-96-dominant expression ( ). Conclusion. The expression patterns of both LINC01314 and miR-96 may be diagnostic of, and prognostic for, CRC. These findings will facilitate further exploration of the molecular mechanism of lncRNAs in CRC.