Liang Zhao
Liang Zhao has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Guanglie Zhang
City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China
1 shared publication - Hongyu Zhang
Department of Mechanical Engineering, City University of Hong Kong, Hong Kong SAR 999077, China
1 shared publication - Jianghong Xu
Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066004, China
1 shared publication - Wen Jung Li
City University of Hong Kong
1 shared publication - Xiaoai Wang
Sensor and Big Data Laboratory, Northeastern University, Qinhuangdao 066000, China
1 shared publication - Yang Li
Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China
1 shared publication
Latest Publications
- Open Access
- 21 October 2022
- Published by MDPI AG in Biosensors
- Vol. 12 (10) , 902
Glycated Hemoglobin Electrochemical Immunosensor Based on Screen-Printed Electrode
An electrochemical HbA1c sensor with high sensitivity and good specificity is proposed based on the electrochemical immune principle. The reproducibility and conductivity of the electrode are improved by depositing gold nanoparticles (AuNPs) on the surface of the screen-printed electrode (SPE). The HbA1c antibodies are immobilized on the surface of the modified electrode by adsorption to capture the HbA1c in the sample. The hindering effect of HbA1c on the electrode transfer reaction was exploited as the HbA1c detection mechanism. The electrode’s properties were characterized by electrochemical impedance spectroscopy (EIS), and the measurement properties of the electrode were analyzed using differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The experimental results show that the peak current signal of the electrochemical immunosensor produced a linear response to HbA1c in the concentration range of 20–200 μg/mL, a linear relationship coefficient of 0.9812, a detection limit of 15.5 µg/mL, and a sensitivity of 0.0938 µA/µg·mL−1. The sensor delivered satisfactory repeatability, stability, and anti-interference performance. Due to its small size, high sensitivity, and wide linear detection range, it is expected to play a significant role in managing diabetes at home.
- 21 October 2022
- Published by MDPI AG in Biosensors
- Vol. 12 (10) , 902
Open AccessGlycated Hemoglobin Electrochemical Immunosensor Based on Screen-Printed Electrode
An electrochemical HbA1c sensor with high sensitivity and good specificity is proposed based on the electrochemical immune principle. The reproducibility and conductivity of the electrode are improved by depositing gold nanoparticles (AuNPs) on the surface of the screen-printed electrode (SPE). The HbA1c antibodies are immobilized on the surface of the modified electrode by adsorption to capture the HbA1c in the sample. The hindering effect of HbA1c on the electrode transfer reaction was exploited as the HbA1c detection mechanism. The electrode’s properties were characterized by electrochemical impedance spectroscopy (EIS), and the measurement properties of the electrode were analyzed using differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The experimental results show that the peak current signal of the electrochemical immunosensor produced a linear response to HbA1c in the concentration range of 20–200 μg/mL, a linear relationship coefficient of 0.9812, a detection limit of 15.5 µg/mL, and a sensitivity of 0.0938 µA/µg·mL−1. The sensor delivered satisfactory repeatability, stability, and anti-interference performance. Due to its small size, high sensitivity, and wide linear detection range, it is expected to play a significant role in managing diabetes at home.