Federico Vittorio Rossi
Research Subjects
Federico Vittorio Rossi has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Andrea Francesca Quivelli
Dipartimento di Farmacia—Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
1 shared publication - Chiara Alario
Laboratori Alchemia S.r.l., Via San Faustino 68, I-20134 Milan, Italy
1 shared publication - Filippo Maria Perna
Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Consorzio CINMPIS, via E. Orabona 4, 70125 Bari, Italy
1 shared publication - Francesco Sannicolò
Laboratori Alchemia S.r.l., Via San Faustino 68, I-20134 Milan, Italy
1 shared publication - Joaquín García-Álvarez
Laboratorio de Química Sintética Sostenible (QuimSinSos), Departamento de Química Orgánica e Inorgánica, (IUQOEM), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Química, Universidad de Oviedo, E33071 Oviedo, Spain
1 shared publication - Paola Vitale
Dipartimento di Farmacia-Scienze del Farmaco Consorzio C.I.N.M.P.I.S. Università degli Studi di Bari “Aldo Moro” Via E. Orabona 4 70125 Bari Italy
1 shared publication
Latest Publications
- Open Access
Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach
Dimethindene is a selective histamine H1 antagonist and is commercially available as a racemate. Upon analyzing the synthetic pathways currently available for the industrial preparation of dimethindene, we set up a sustainable approach for the synthesis of this drug, switching from petroleum-based volatile organic compounds (VOCs) to eco-friendly solvents, such as 2-methyltetrahydrofuran (2-MeTHF) and cyclopentyl methyl ether (CPME) belonging to classes 3 and 2, respectively. Beyond decreasing the environmental impact of the synthesis (E-factor: 24.1–54.9 with VOCs; 12.2–22.1 with 2-MeTHF or CPME), this switch also improved the overall yield of the process (from 10% with VOCs to 21–22% with 2-MeTHF or CPME) and remarkably simplified the manual operations, working under milder conditions. Typical metrics applied at the first and second pass, according to the CHEM21 metrics toolkit, were also calculated for the whole synthetic procedure of dimethindene, and the results were compared with those of the classical procedure.
Open AccessGreen Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach
Dimethindene is a selective histamine H1 antagonist and is commercially available as a racemate. Upon analyzing the synthetic pathways currently available for the industrial preparation of dimethindene, we set up a sustainable approach for the synthesis of this drug, switching from petroleum-based volatile organic compounds (VOCs) to eco-friendly solvents, such as 2-methyltetrahydrofuran (2-MeTHF) and cyclopentyl methyl ether (CPME) belonging to classes 3 and 2, respectively. Beyond decreasing the environmental impact of the synthesis (E-factor: 24.1–54.9 with VOCs; 12.2–22.1 with 2-MeTHF or CPME), this switch also improved the overall yield of the process (from 10% with VOCs to 21–22% with 2-MeTHF or CPME) and remarkably simplified the manual operations, working under milder conditions. Typical metrics applied at the first and second pass, according to the CHEM21 metrics toolkit, were also calculated for the whole synthetic procedure of dimethindene, and the results were compared with those of the classical procedure.