Roberta De Rose
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Roberta De Rose has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Carlo Siciliano
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, I-87036 Rende, Italy
1 shared publication - Debora Procopio
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
1 shared publication - Maria Luisa Di Gioia
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
1 shared publication - Roberta Cassano
Department of Pharmacy, Health and Nutritional Science, University of Calabria, 87036 Rende, Italy
1 shared publication - Sonia Trombino
Department of Pharmacy, Health and Nutritional Science, University of Calabria, 87036 Rende, Italy
1 shared publication
Latest Publications
- Open Access
A Brønsted Acidic Deep Eutectic Solvent for N-Boc Deprotection
The tert-butyloxycarbonyl (Boc) group is one of the most widely used amine-protecting groups in multistep reactions in synthetic organic chemistry as well as in peptide synthesis. Traditional methods to remove the Boc group have disadvantages in terms of high acidity, the use of expensive reagents, excessive amounts of catalysts and harmful solvents as well as high temperatures, making them environmentally unsustainable. Therefore, more efforts must be stepwise tightened to make Boc removal practical, clean, and minimize any potential impact. We describe an efficient and sustainable method for N-Boc deprotection by means of a choline chloride/p-toluenesulfonic acid deep eutectic solvent (DES), which is used as a reaction medium plus catalyst. The adopted conditions allow the deprotection of a wide variety of N-Boc derivatives in excellent yields. The strategy has found advantages in greening, simplicity, and short reaction times, resulting in a useful alternative to standard methods.
Open AccessA Brønsted Acidic Deep Eutectic Solvent for N-Boc Deprotection
The tert-butyloxycarbonyl (Boc) group is one of the most widely used amine-protecting groups in multistep reactions in synthetic organic chemistry as well as in peptide synthesis. Traditional methods to remove the Boc group have disadvantages in terms of high acidity, the use of expensive reagents, excessive amounts of catalysts and harmful solvents as well as high temperatures, making them environmentally unsustainable. Therefore, more efforts must be stepwise tightened to make Boc removal practical, clean, and minimize any potential impact. We describe an efficient and sustainable method for N-Boc deprotection by means of a choline chloride/p-toluenesulfonic acid deep eutectic solvent (DES), which is used as a reaction medium plus catalyst. The adopted conditions allow the deprotection of a wide variety of N-Boc derivatives in excellent yields. The strategy has found advantages in greening, simplicity, and short reaction times, resulting in a useful alternative to standard methods.