Margaret Coe
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Margaret Coe has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Beatrix Jones
Department of Statistics, University of Auckland, Auckland 1010, New Zealand
1 shared publication - Chris Pook
The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
1 shared publication - Eric Bruce Thorstensen
Liggins Institute, University of Auckland, Auckland 1010, New Zealand
1 shared publication - Githal Randunu Porawakara Arachchige
The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
1 shared publication - Justin Martin O'Sullivan
Liggins Institute, The University of Auckland, Auckland, New Zealand
1 shared publication - Melissa Wake
Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia
1 shared publication
Latest Publications
- Open Access
Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children
Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating levels, but no studies have reported on the population epidemiology of FSV in these groups as of yet. In this study, we report distributions of FSV, their parent-child concordance and variation by key characteristics for 2490 children (aged 11–12 years) and adults (aged 28–71 years) in the Child Health CheckPoint of the Longitudinal Study of Australian Children. Ten A, D, E and K vitamers were quantified using a novel automated LC-MS/MS method. All three K vitamers (i.e., K1, MK-4, MK-7) and 1-α-25(OH)2D3 were below the instrument detection limit and were removed from the present analysis. We observed a strong vitamer-specific parent-child concordance for the six quantifiable A, D and E FSVs. FSV concentrations all varied by age, BMI, and sex. We provide the first cross-sectional population values for multiple FSV. Future studies could examine relative genetic vs. environmental determinants of FSV, how FSV values change longitudinally, and how they contribute to future health and disease.
Open AccessFat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children
Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating levels, but no studies have reported on the population epidemiology of FSV in these groups as of yet. In this study, we report distributions of FSV, their parent-child concordance and variation by key characteristics for 2490 children (aged 11–12 years) and adults (aged 28–71 years) in the Child Health CheckPoint of the Longitudinal Study of Australian Children. Ten A, D, E and K vitamers were quantified using a novel automated LC-MS/MS method. All three K vitamers (i.e., K1, MK-4, MK-7) and 1-α-25(OH)2D3 were below the instrument detection limit and were removed from the present analysis. We observed a strong vitamer-specific parent-child concordance for the six quantifiable A, D and E FSVs. FSV concentrations all varied by age, BMI, and sex. We provide the first cross-sectional population values for multiple FSV. Future studies could examine relative genetic vs. environmental determinants of FSV, how FSV values change longitudinally, and how they contribute to future health and disease.