Alessio Sferrazza
Research Subjects
Alessio Sferrazza has a total of 35 co-authors. Here are the top co-authors by number of shared publications:
- Antonella Goggiamani
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P. le A. Moro 5, 00185 Rome, Italy
4 shared publications - Antonia Iazzetti
Dipartimento di Scienze Biotecnologiche di Base Cliniche Intensivologiche e Perioperatorie Università Cattolica del Sacro Cuore Rome Italy
4 shared publications - Giancarlo Fabrizi
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P. le A. Moro 5, 00185 Rome, Italy
3 shared publications - Antonio Arcadi
Dipartimento di Scienze Fisiche e Chimiche, Università degli studi dell’Aquila, Via Vetoio, Coppito (AQ), 67100 L’Aquila,Italy
2 shared publications - Federico Marrone
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P. le A. Moro 5, 00185 Rome, Italy
2 shared publications - Karim Ullah
Department of Chemistry, Sustainable Chemistry for Metals and Molecules (SCM2), KU Leuven, Celestijnenlaan 200F, box 2404, Leuven, Belgium, 3001
2 shared publications
Latest Publications
- 20 August 2025
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 129, 130383
Novel azabicyclic series of potent SHP2 allosteric inhibitors
- 20 August 2025
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 129, 130383
Novel azabicyclic series of potent SHP2 allosteric inhibitors
- Open Access
Synthesis of Functionalized 3H-pyrrolo-[1,2,3-de] Quinoxalines via Gold-Catalyzed Intramolecular Hydroamination of Alkynes
A gold-catalyzed protocol to obtain functionalized 3H-pyrrolo [1,2,3-de] quinoxalines from suitable substituted N-alkynyl indoles has been proposed. The mild reaction conditions were revealed to be compatible with different functional groups, including halogen, alkoxyl, cyano, ketone, and ester, allowing the isolation of title compounds with yields from good to high. A reaction mechanism has been proposed, and theoretical calculations have been provided to rationalize the final step of the hypothesized reaction mechanism. As quinoxaline-containing polycyclic compounds, this class of molecules may represent a valuable template in medicinal chemistry and material science.
Open AccessSynthesis of Functionalized 3H-pyrrolo-[1,2,3-de] Quinoxalines via Gold-Catalyzed Intramolecular Hydroamination of Alkynes
A gold-catalyzed protocol to obtain functionalized 3H-pyrrolo [1,2,3-de] quinoxalines from suitable substituted N-alkynyl indoles has been proposed. The mild reaction conditions were revealed to be compatible with different functional groups, including halogen, alkoxyl, cyano, ketone, and ester, allowing the isolation of title compounds with yields from good to high. A reaction mechanism has been proposed, and theoretical calculations have been provided to rationalize the final step of the hypothesized reaction mechanism. As quinoxaline-containing polycyclic compounds, this class of molecules may represent a valuable template in medicinal chemistry and material science.
- Open Access
- 27 March 2023
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 13 (15) , 10090-10096
Synthesis of 3-substituted 2,3-dihydropyrazino[1,2- a ]indol-4(1 H )-ones by sequential reactions of 2-indolylmethyl acetates with α-amino acids
The synthesis of 2,3-dihydropyrazino[1,2- a ]indol-4(1 H )-ones through the in situ generation of 2-methide-2 H -indole intermediate I starting from 2-indolylmethyl acetates under basic conditions/nucleophilic Michael addition/cyclization cascade reaction.
- 27 March 2023
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 13 (15) , 10090-10096
Open AccessSynthesis of 3-substituted 2,3-dihydropyrazino[1,2- a ]indol-4(1 H )-ones by sequential reactions of 2-indolylmethyl acetates with α-amino acids
The synthesis of 2,3-dihydropyrazino[1,2- a ]indol-4(1 H )-ones through the in situ generation of 2-methide-2 H -indole intermediate I starting from 2-indolylmethyl acetates under basic conditions/nucleophilic Michael addition/cyclization cascade reaction.
- Open Access
Highly Efficient and Mild Gold (I) Catalyzed Synthesis of 3,8-Diarylidene-2,7-dioxaspiro[4.4]nonane-1,6-diones
The gold-catalyzed cyclization of 2,2-bis(3-arylprop-2-yn1-yl)malonic acid has been proposed as an efficient approach to substituted 3,8-dibenzyl-2,7-dioxaspiro[4.4]nonane-1,6-diones. The reaction proceeds smoothly in mild reaction conditions to give the desired products in quantitative yields in the presence of variously substituted starting materials. In addition, the synthesis of γ-arylidene spirobislactone bearing different substituents on the two aromatic rings has been achieved. This kind of compound could be of great interest in pharmaceutical science given the widespread presence of this scaffold in bioactive natural and synthetic products.
Open AccessHighly Efficient and Mild Gold (I) Catalyzed Synthesis of 3,8-Diarylidene-2,7-dioxaspiro[4.4]nonane-1,6-diones
The gold-catalyzed cyclization of 2,2-bis(3-arylprop-2-yn1-yl)malonic acid has been proposed as an efficient approach to substituted 3,8-dibenzyl-2,7-dioxaspiro[4.4]nonane-1,6-diones. The reaction proceeds smoothly in mild reaction conditions to give the desired products in quantitative yields in the presence of variously substituted starting materials. In addition, the synthesis of γ-arylidene spirobislactone bearing different substituents on the two aromatic rings has been achieved. This kind of compound could be of great interest in pharmaceutical science given the widespread presence of this scaffold in bioactive natural and synthetic products.
- Open Access
Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives
A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
Open AccessSynthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives
A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.