Noor A. Al-Maslamani
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Noor A. Al-Maslamani has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Henning F. Horn
College of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar
1 shared publication - Jude Curran
Department of Mechanical, Materials and Aerospace Engineering, School of Engineering, University of Liverpool, Liverpool L69 3GH, UK
1 shared publication - Kazuhiro Yamamoto
Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
1 shared publication - Pieter D'HOoghe
Department of Orthopaedic Surgery and Sportsmedicine, Aspetar Hospital, Doha 29222, Qatar
1 shared publication - Rachel A. Oldershaw
Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK
1 shared publication - Simon R. Tew
Institute of Ageing and Chronic Disease, University of Liverpool, UK
1 shared publication
Latest Publications
- Open Access
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The expansion process provides the benefit of generating a large number of cells required for implantation; however, during the expansion these cells de-differentiate and lose their chondrocyte phenotype. In this review we focus on examining the de-differentiation phenotype from a mechanobiology and biophysical perspective, highlighting some of the nuclear mechanics and chromatin changes in chondrocytes seen during the expansion process and how this relates to the gene expression profile. We propose that manipulating chondrocyte nuclear architecture and chromatin organization will highlight mechanisms that will help to preserve the chondrocyte phenotype.
Open AccessChondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The expansion process provides the benefit of generating a large number of cells required for implantation; however, during the expansion these cells de-differentiate and lose their chondrocyte phenotype. In this review we focus on examining the de-differentiation phenotype from a mechanobiology and biophysical perspective, highlighting some of the nuclear mechanics and chromatin changes in chondrocytes seen during the expansion process and how this relates to the gene expression profile. We propose that manipulating chondrocyte nuclear architecture and chromatin organization will highlight mechanisms that will help to preserve the chondrocyte phenotype.