Rasha F. El-Agamy

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths globally, making a timely and reliable diagnosis essential. Manual histopathology assessment, though clinically standard, is prone to observer variability, while existing computational approaches often trade accuracy for interpretability, limiting their clinical utility. This paper introduces a deep learning framework that couples the YOLOv8 architecture for multiclass lesion classification with EigenCAM for transparent model explanations. The pipeline integrates three core stages: (i) acquisition and preprocessing of 5000 hematoxylin-and-eosin-stained slides from the University Medical Center Mannheim, categorized into eight tissue types; (ii) comparative evaluation of five YOLOv8 variants (Nano, Small, Medium, Large, XLarge); and (iii) interpretability through EigenCAM visualizations to highlight discriminative regions driving predictions. Extensive statistical validation (including box plots, empirical cumulative distribution functions, Bland–Altman plots, and pair plots) demonstrated the robustness and reliability of the framework. The YOLOv8 XLarge model achieved 99.38% training accuracy and 96.62% testing accuracy, outperforming recent CNN- and Transformer-based systems (≤95%). This framework establishes a clinically dependable foundation for AI-assisted CRC diagnosis by uniting high precision with visual interpretability. It represents a significant step toward real-world deployment in pathology workflows.

Unrecognized mechanical faults and emergency sounds in vehicles can compromise safety, particularly for individuals with hearing impairments and in sound-insulated or autonomous driving environments. As intelligent transportation systems (ITSs) evolve, there is a growing need for inclusive, non-intrusive, and real-time diagnostic solutions that enhance situational awareness and accessibility. This study introduces an interpretable, sound-based machine learning framework to detect vehicle faults and emergency sound events using acoustic signals as a scalable diagnostic source. Three purpose-built datasets were developed: one for vehicular fault detection, another for emergency and environmental sounds, and a third integrating both to reflect real-world ITS acoustic scenarios. Audio data were preprocessed through normalization, resampling, and segmentation and transformed into numerical vectors using Mel-Frequency Cepstral Coefficients (MFCCs), Mel spectrograms, and Chroma features. To ensure performance and interpretability, feature selection was conducted using SHAP (explainability), Boruta (relevance), and ANOVA (statistical significance). A two-phase experimental workflow was implemented: Phase 1 evaluated 15 classical models, identifying ensemble classifiers and multi-layer perceptrons (MLPs) as top performers; Phase 2 applied advanced feature selection to refine model accuracy and transparency. Ensemble models such as Extra Trees, LightGBM, and XGBoost achieved over 91% accuracy and AUC scores exceeding 0.99. SHAP provided model transparency without performance loss, while ANOVA achieved high accuracy with fewer features. The proposed framework enhances accessibility by translating auditory alarms into visual/haptic alerts for hearing-impaired drivers and can be integrated into smart city ITS platforms via roadside monitoring systems.

This survey paper comprehensively reviews Digital Twin (DT) technology, a virtual representation of a physical object or system, pivotal in Smart Cities for enhanced urban management. It explores DT's integration with Machine Learning for predictive analysis, IoT for real-time data, and its significant role in Smart City development. Addressing the gap in existing literature, this survey analyzes over 4,220 articles from the Web of Science, focusing on unique aspects like datasets, platforms, and performance metrics. Unlike other studies in the field, this research paper distinguishes itself through its comprehensive and bibliometric approach, analyzing over 4,220 articles and focusing on unique aspects like datasets, platforms, and performance metrics. This approach offers an unparalleled depth of analysis, enhancing the understanding of Digital Twin technology in Smart City development and setting a new benchmark in scholarly research in this domain. The study systematically identifies emerging trends and thematic topics, utilizing tools like VOSviewer for data visualization. Key findings include publication trends, prolific authors, and thematic clusters in research. The paper highlights the importance of DT in various urban applications, discusses challenges and limitations, and presents case studies showcasing successful implementations. Distinguishing from prior studies, it offers detailed insights into emerging trends, future research directions, and the evolving role of policy and governance in DT development, thereby making a substantial contribution to the field.

Automatic key gesture detection and recognition are difficult tasks in Human–Computer Interaction due to the need to spot the start and the end points of the gesture of interest. By integrating Hidden Markov Models (HMMs) and Deep Neural Networks (DNNs), the present research provides an autonomous technique that carries out hand gesture spotting and prediction simultaneously with no time delay. An HMM can be used to extract features, spot the meaning of gestures using a forward spotting mechanism with varying sliding window sizes, and then employ Deep Neural Networks to perform the recognition process. Therefore, a stochastic strategy for creating a non-gesture model using HMMs with no training data is suggested to accurately spot meaningful number gestures (0–9). The non-gesture model provides a confidence measure, which is utilized as an adaptive threshold to determine where meaningful gestures begin and stop in the input video stream. Furthermore, DNNs are extremely efficient and perform exceptionally well when it comes to real-time object detection. According to experimental results, the proposed method can successfully spot and predict significant motions with a reliability of 94.70%.