Antonella V. Dan Córdoba
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Antonella V. Dan Córdoba has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Ariana Zoppi
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA-CONICET, Facultad de Ciencias Químicas, Departamento de Ciencias Farmacéuticas, Universidad Nacional de Córdoba, Córdoba, Argentina
2 shared publications - Marcela Raquel Longhi
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina
2 shared publications - Mario Alfredo Quevedo
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (FCQ-UNC), Haya de la Torre y Medina Allende, Córdoba 5000, Argentina
2 shared publications - Virginia Aiassa
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina
2 shared publications - Camila N. Barrionuevo
Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, Facultad Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
1 shared publication - Jesica Ayelen Dimmer
Centro de Investigación de la Enfermedad de Chagas y Leishmaniasis (CIECyL), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina; Centro de Investigaciones y Transferencia Villa María (CIT-VM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Villa María, Argentina
1 shared publication
Latest Publications
- Open Access
- 5 January 2023
- Published by MDPI AG in Pharmaceutics
- Vol. 15 (1) , 198
Development and Characterization of Pharmaceutical Systems Containing Rifampicin
Rifampicin is a potent antimicrobial drug with some suboptimal properties, such as poor stability, low solubility, and variable bioavailability. Therefore, in the current study, a multicomponent complex between rifampicin, γ-cyclodextrin, and arginine was prepared with the aim of improving drug properties. Solubility was evaluated by phase-solubility studies. The mechanism of interaction was established through proton nuclear magnetic resonance spectroscopy and molecular modeling. Physicochemical characterization was investigated using Fourier transform-infrared spectroscopy, powder X-ray diffraction, and scanning electron microscopy. The dissolution properties, antimicrobial activity (antibacterial, antibiofilm, and antileishmanial), and stability of the different samples were studied. The results obtained in this investigation demonstrate that multicomponent complexes can improve the water solubility and dissolution rate of rifampicin, as well as its antibacterial and antileishmanial action, and present suitable stability. In conclusion, rifampicin complexed with γ-cyclodextrin and arginine is an attractive approach for developing pharmaceutical dosage forms of rifampicin with increased antimicrobial activities.
- 5 January 2023
- Published by MDPI AG in Pharmaceutics
- Vol. 15 (1) , 198
Open AccessDevelopment and Characterization of Pharmaceutical Systems Containing Rifampicin
Rifampicin is a potent antimicrobial drug with some suboptimal properties, such as poor stability, low solubility, and variable bioavailability. Therefore, in the current study, a multicomponent complex between rifampicin, γ-cyclodextrin, and arginine was prepared with the aim of improving drug properties. Solubility was evaluated by phase-solubility studies. The mechanism of interaction was established through proton nuclear magnetic resonance spectroscopy and molecular modeling. Physicochemical characterization was investigated using Fourier transform-infrared spectroscopy, powder X-ray diffraction, and scanning electron microscopy. The dissolution properties, antimicrobial activity (antibacterial, antibiofilm, and antileishmanial), and stability of the different samples were studied. The results obtained in this investigation demonstrate that multicomponent complexes can improve the water solubility and dissolution rate of rifampicin, as well as its antibacterial and antileishmanial action, and present suitable stability. In conclusion, rifampicin complexed with γ-cyclodextrin and arginine is an attractive approach for developing pharmaceutical dosage forms of rifampicin with increased antimicrobial activities.
- 2 June 2020
- Published by Springer Nature in AAPS PharmSciTech
- Vol. 21 (5) , 1-13
Improved Activity of Rifampicin Against Biofilms of Staphylococcus aureus by Multicomponent Complexation
The aim of this study was to evaluate a multicomponent complex (MC) between rifampicin (RIF), β-cyclodextrin (β-CD), and selected amino acids to
- 2 June 2020
- Published by Springer Nature in AAPS PharmSciTech
- Vol. 21 (5) , 1-13
Improved Activity of Rifampicin Against Biofilms of Staphylococcus aureus by Multicomponent Complexation
The aim of this study was to evaluate a multicomponent complex (MC) between rifampicin (RIF), β-cyclodextrin (β-CD), and selected amino acids to