Yunshan Zhou

Mustard gas (HD) causes ulcerative skin wounds; however, owing to its multiple mechanisms of action, no officially approved specific antidote has been developed to date. Moreover, current therapeutic materials for HD-induced skin injuries generally overlook the potential retention of residual HD at the wound site, which may adversely affect the healing process. Herein, a Janus membrane was rationally designed and successfully fabricated by electrospinning a blend of curcumin (denoted Cur)-loaded γ-cyclodextrin metal-organic framework (Cur@γ-CD-MOF) and polyacrylonitrile (PAN) onto a chitosan nonwoven fabric (CS-NWF) substrate, yielding a material with both pH-responsive drug release and HD detoxification capabilities. The resulting membrane was systematically characterized using IR, P-XRD, SEM, BET, TG and other techniques. The experimental results showed that the Cur@γ-CD-MOF@PAN side of the Janus membrane improved the aqueous solubility of Cur and enabled sustained, on-demand release. The skin-contacting CS-NWF side exhibited hemostatic capability, and Cur released from the membrane to the skin together with CS is thought to exert synergistic antioxidant effects. Moreover, the Janus membrane exhibited notable detoxification performance toward the HD simulant 2-chloroethyl ethyl sulfide and enabled real-time visual monitoring of the detoxification process through a steady color change of the system from red to yellow. Remarkably, in a guinea pig model of cutaneous HD intoxication, this Janus membrane showed a good therapeutic effect on HD-injured skin.

Keplerate-type nano-polyoxometalates are efficient catalysts for selective CEES oxidation using water as solvent and H ₂ O ₂ as oxidant, whilst revealing ligand-based catalyst charge regulation effect.

Developing materials capable of rapidly decontaminating nerve and blister agents directly under ambient conditions are crucial for practical applications. In this work, Mg ₃ Al _{1‐ x} Zr _x ‐LDH with different Zr ⁴⁺ doping contents and corresponding OH ⁻ intercalated materials Mg ₃ Al _{1‐ x} Zr _x ‐LDH‐OH are synthesized. First, they are used for the decontamination of nerve agents under ambient conditions, showing that increasing the Zr ⁴⁺ doping amount accelerates the decontamination rate of diethyl cyanophosphonate (DECP) and soman (GD), with the half‐life of DECP and GD being 3–5 times shorter with Mg ₃ Al _0.6 Zr _0.4 ‐LDH (the highest Zr ⁴⁺ doping content) compared to Mg ₃ Al ₁ ‐LDH. Notably, the intercalation of OH ⁻ in Mg ₃ Al _0.6 Zr _0.4 ‐LDH further greatly enhances the catalytic activity for DECP and GD, the reaction half‐life of DECP and GD with Mg ₃ Al _0.6 Zr _0.4 ‐LDH‐OH being 18 s and 3 Al _0.6 Zr _0.4 ‐LDH‐OH exhibits superior detoxification performance for mustard gas (HD) compared to Mg ₃ Al _0.6 Zr _0.4 ‐LDH, with 92.8% of HD being removed within 6 h. Mechanistic studies reveal that Mg ₃ Al _0.6 Zr _0.4 ‐LDH‐OH efficiently decontaminates nerve and blister agents utilizing the synergistic effect of Lewis acid‐base sites (Zr ⁴⁺ and laminate OH groups) and interlayer OH ⁻ . To extend the practical applications of the materials, PVA@(PAN/LDH‐OH) self‐detoxifying fiber loaded with Mg ₃ Al _0.6 Zr _0.4 ‐LDH‐OH is prepared.

OxTMB and Ce³⁺-GSH-Au NCs, prepared by a cascade reaction, were used to achieve the dual-signal readout of the nerve agent sarin.

A fluorescent Eu-MOF showed high selectivity and sensitivity for the assay of DMNP, which was further extended to fabricate logic gates and a fibrous strip for the in situ visual detection of DMNP.