L Gregoret
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
L Gregoret has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
A Baucom
Chemistry & Biochemistry University of California 95064 Santa Cruz CA USA
1 shared publicationJ Bentz
Departments of Biology, Computer Science and Chemistry & Biochemistry, University of California, Santa Cruz, CA 95064, USA
1 shared publicationM Hansen
Chemistry & Biochemistry University of California 95064 Santa Cruz CA USA
1 shared publication
Latest Publications
- Open Access
- 1 April 1999
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 15 (4) , 309-316
DINAMO: interactive protein alignment and model building.
MOTIVATION: To facilitate the process of structure prediction by both comparative modeling and fold recognition, we describe DINAMO, an interactive protein alignment building and model evaluation tool that dynamically couples a multiple sequence alignment editor to a molecular graphics display. DINAMO allows the user to optimize the alignment and model to satisfy the known heuristics of protein structure by means of a set of analysis tools. The analysis tools return information to both the alignment editor and graphics model in the form of visual cues (color, shape), allowing for rapid evaluation. Several analysis tools may be employed, including residue conservation, residue properties (charge, hydrophobicity, volume), residue environmental preference, and secondary structure propensity. RESULTS: We demonstrate DINAMO by building a model for submission in the 3rd annual Critical Assessment of Techniques for Protein Structure Prediction (CASP3) contest. AVAILABILITY: DINAMO is freely available as a local application or Web-based Java applet at http://tito.ucsc.edu/dinamo
- 1 April 1999
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 15 (4) , 309-316
Open AccessDINAMO: interactive protein alignment and model building.
MOTIVATION: To facilitate the process of structure prediction by both comparative modeling and fold recognition, we describe DINAMO, an interactive protein alignment building and model evaluation tool that dynamically couples a multiple sequence alignment editor to a molecular graphics display. DINAMO allows the user to optimize the alignment and model to satisfy the known heuristics of protein structure by means of a set of analysis tools. The analysis tools return information to both the alignment editor and graphics model in the form of visual cues (color, shape), allowing for rapid evaluation. Several analysis tools may be employed, including residue conservation, residue properties (charge, hydrophobicity, volume), residue environmental preference, and secondary structure propensity. RESULTS: We demonstrate DINAMO by building a model for submission in the 3rd annual Critical Assessment of Techniques for Protein Structure Prediction (CASP3) contest. AVAILABILITY: DINAMO is freely available as a local application or Web-based Java applet at http://tito.ucsc.edu/dinamo