Ke Liang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Ke Liang has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
Shi-Bing Zhang
Department of Pharmacy, The SuqianFirst Hospital, Suqian, Jiangsu 223800, China
1 shared publicationShi-Meng Li
Department of Pharmacy, The SuqianFirst Hospital, Suqian, Jiangsu 223800, China
1 shared publicationXin Jin
Department of Pharmacy, The SuqianFirst Hospital, Suqian, Jiangsu 223800, China
1 shared publication- Zeng-Yong Jia
Department of Hospital Pharmacy, The First Hospital of Suqian, Suqian, Jiangsu, China
1 shared publication
Latest Publications
- Open Access
- 1 January 2016
- Published by SAGE Publications in Pharmacognosy Magazine
- Vol. 12 (45) , 57-63
Influence of chitosan nanoparticles as the absorption enhancers on salvianolic acid B In vitro and In vivo evaluation
Background: Salvianolic acid B (SalB) represents the most abundant and bio-active phenolic constituent among the water-soluble compounds of Salvia miltiorrhiza. But the therapeutic potential of SalB has been significantly restricted by its poor absorption. Methods: In this study, chitosans (CS) and CS nanoparticles (NPs) with different molecular weights (MWs), which have influence on the absorption of SalB, was also investigated. Results: As a preliminary study, water-soluble CS with various MWs (3, 30, 50, and 100 kDa) was chosen. We investigated the MW-dependent Caco-2 cell layer transport phenomena in vitro of CS and NPs at concentrations (4 μg/ml, w/v). SalB, in presence CS or NPs has no significant toxic effect on Caco-2 cell. As the MW increases, the absorption enhancing effect of CS increases. However, as the MW decreases, the absorption enhancing effect of NPs increases. The AUC 0-∞ of the SalB-100 kDa CS was 4.25 times greater than that of free SalB. And the AUC 0-∞ of the SalB-3 kDa NPs was 16.03 times greater than that of free SalB. Conclusion: CS and NPs with different MWs as the absorption enhancers can promote the absorption of SalB. And the effect on NPs is better than CS.
- 1 January 2016
- Published by SAGE Publications in Pharmacognosy Magazine
- Vol. 12 (45) , 57-63
Open AccessInfluence of chitosan nanoparticles as the absorption enhancers on salvianolic acid B In vitro and In vivo evaluation
Background: Salvianolic acid B (SalB) represents the most abundant and bio-active phenolic constituent among the water-soluble compounds of Salvia miltiorrhiza. But the therapeutic potential of SalB has been significantly restricted by its poor absorption. Methods: In this study, chitosans (CS) and CS nanoparticles (NPs) with different molecular weights (MWs), which have influence on the absorption of SalB, was also investigated. Results: As a preliminary study, water-soluble CS with various MWs (3, 30, 50, and 100 kDa) was chosen. We investigated the MW-dependent Caco-2 cell layer transport phenomena in vitro of CS and NPs at concentrations (4 μg/ml, w/v). SalB, in presence CS or NPs has no significant toxic effect on Caco-2 cell. As the MW increases, the absorption enhancing effect of CS increases. However, as the MW decreases, the absorption enhancing effect of NPs increases. The AUC 0-∞ of the SalB-100 kDa CS was 4.25 times greater than that of free SalB. And the AUC 0-∞ of the SalB-3 kDa NPs was 16.03 times greater than that of free SalB. Conclusion: CS and NPs with different MWs as the absorption enhancers can promote the absorption of SalB. And the effect on NPs is better than CS.