Youhui Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

*This is an algorithmically generated author record based on publicly available information.

See Latest Publications

See Most Cited Publications

ORCID Profile

Google Scholar

Current Organizations / Institutes

The organizations/institutes from the scholar's latest article

Chinese Academy of Medical Sciences & Peking Union Medical College

Research Subjects

Research Interests

Youhui Zhang has a total of 15 co-authors. Here are the top co-authors by number of shared publications:

Hui Dai
Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China
12 shared publications
Jinfeng Chen
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China
12 shared publications
Jing Huang
Department of Immunology, School of Basic Medical Sciences, and NHC Key Laboratory of Medical Immunology, Peking University , Beijing , China
12 shared publications
Jingshu Tang
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China
12 shared publications
Jingxuan Zhang
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China
12 shared publications
Liang Zhang
Department of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Hong Kong, China
12 shared publications

Latest Publications

Sort by

Open Access
Website
Google Scholar
- 24 November 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 24 November 2025
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
Cited by 1
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the monoclonal antibody RP215, which specifically recognizes the Asn162 sialylation-related epitope on SIA-cIgG, effectively blocked the SIA-cIgG-driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.
Website
Google Scholar
- 16 September 2024
- Published by American Association for Cancer Research (AACR)
Open Access
Data from A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the monoclonal antibody RP215, which specifically recognizes the Asn162 sialylation-related epitope on SIA-cIgG, effectively blocked the SIA-cIgG-driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.
Cited by 1
Open Access
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the mAb RP215, which specifically recognizes the Asn162 sialylation–related epitope on SIA-cIgG, effectively blocked the SIA-cIgG–driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.Significance:Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the mAb RP215, which specifically recognizes the Asn162 sialylation–related epitope on SIA-cIgG, effectively blocked the SIA-cIgG–driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.Significance:Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.
Open Access
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the mAb RP215, which specifically recognizes the Asn162 sialylation–related epitope on SIA-cIgG, effectively blocked the SIA-cIgG–driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.Significance:Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.
Website
Google Scholar
- 2 June 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the mAb RP215, which specifically recognizes the Asn162 sialylation–related epitope on SIA-cIgG, effectively blocked the SIA-cIgG–driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.Significance:Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.
Open Access
Website
Google Scholar
- 18 May 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 18 May 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Open Access
Website
Google Scholar
- 18 May 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.
Website
Google Scholar
- 18 May 2023
- Published by American Association for Cancer Research (AACR)
Open Access
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
by Xinmei Huang, Shenghua Zhang, Jingshu Tang, Tian Tian, Yilin Pan, Lina Wu, Jingxuan Zhang, Yang Liu, Jing Huang, Hui Dai, et al.
Supplementary figures and tables.

Show all