Xiang Li
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Research Interests
Xiang Li has a total of 15 co-authors. Here are the top co-authors by number of shared publications:
- Chun Wang
Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
1 shared publication Hanting Liang
Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
1 shared publication- Jiemei Gu
Shanghai Clinical Research Center of Bone Disease & Department of Osteoporosis and Bone Diseases, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
1 shared publication Jinliang Chen
1 shared publicationJiudan Zhang
1 shared publicationMing Wang
Department of Urology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
1 shared publication
Latest Publications
- Open Access
- 26 September 2026
- Published by Elsevier in AACE Endocrinology and Diabetes
Familial Renal Glucosuria Unmasked by Genetic Testing: A Case Report Highlighting the Diagnostic Challenge of Normoglycemic Glycosuria
- 26 September 2026
- Published by Elsevier in AACE Endocrinology and Diabetes
Open AccessFamilial Renal Glucosuria Unmasked by Genetic Testing: A Case Report Highlighting the Diagnostic Challenge of Normoglycemic Glycosuria
- Open Access
- 11 November 2025
- Published by Wolters Kluwer Health in International Journal of Surgery
- Vol. 112 (2) , 5523-5524
Letter to the Editor “Tertiary hyperparathyroidism” in kidney transplant recipients: a misnomer?
- 11 November 2025
- Published by Wolters Kluwer Health in International Journal of Surgery
- Vol. 112 (2) , 5523-5524
Open AccessLetter to the Editor “Tertiary hyperparathyroidism” in kidney transplant recipients: a misnomer?
- Open Access
Clinical and Genetic Characteristics of Hypophosphatasia in Chinese Adults
Hypophosphatasia (HPP) is an inherited disease caused by ALPL mutation, resulting in decreased alkaline phosphatase (ALP) activity and damage to bone and tooth mineralization. The clinical symptoms of adult HPP are variable, making diagnosis challenging. This study aims to clarify the clinical and genetic characteristics of HPP in Chinese adults. There were 19 patients, including 1 with childhood-onset and 18 with adult-onset HPP. The median age was 62 (32–74) years and 16 female patients were involved. Common symptoms included musculoskeletal symptoms (12/19), dental problems (8/19), fractures (7/19), and fatigue (6/19). Nine patients (47.4%) were misdiagnosed with osteoporosis and six received anti-resorptive treatment. The average serum ALP level was 29.1 (14–53) U/L and 94.7% (18/19) of patients had ALP levels below 40 U/L. Genetic analysis found 14 ALPL mutations, including three novel mutations—c.511C>G (p.His171Ala), c.782C>A (p.Pro261Gln), and 1399A>G (p.Met467Val). The symptoms of two patients with compound heterozygous mutations were more severe than those with heterozygous mutations. Our study summarized the clinical characteristics of adult HPP patients in the Chinese population, expanded the spectrum of pathogenic mutations, and deepened clinicians’ understanding of this neglected disease.
Open AccessClinical and Genetic Characteristics of Hypophosphatasia in Chinese Adults
Hypophosphatasia (HPP) is an inherited disease caused by ALPL mutation, resulting in decreased alkaline phosphatase (ALP) activity and damage to bone and tooth mineralization. The clinical symptoms of adult HPP are variable, making diagnosis challenging. This study aims to clarify the clinical and genetic characteristics of HPP in Chinese adults. There were 19 patients, including 1 with childhood-onset and 18 with adult-onset HPP. The median age was 62 (32–74) years and 16 female patients were involved. Common symptoms included musculoskeletal symptoms (12/19), dental problems (8/19), fractures (7/19), and fatigue (6/19). Nine patients (47.4%) were misdiagnosed with osteoporosis and six received anti-resorptive treatment. The average serum ALP level was 29.1 (14–53) U/L and 94.7% (18/19) of patients had ALP levels below 40 U/L. Genetic analysis found 14 ALPL mutations, including three novel mutations—c.511C>G (p.His171Ala), c.782C>A (p.Pro261Gln), and 1399A>G (p.Met467Val). The symptoms of two patients with compound heterozygous mutations were more severe than those with heterozygous mutations. Our study summarized the clinical characteristics of adult HPP patients in the Chinese population, expanded the spectrum of pathogenic mutations, and deepened clinicians’ understanding of this neglected disease.