Luca Ferlendis
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Luca Ferlendis has a total of 46 co-authors. Here are the top co-authors by number of shared publications:
Davide Locatelli
Division of Neurosurgery, Department of Biotechnology and Life Sciences, Ospedale di Circolo e Fondazione Macchi - ASST dei Sette Laghi, Via Guicciardini, 9, 21100, Varese, Italy
5 shared publications- Pierlorenzo Veiceschi
BIND, Università degli studi di Palermo
4 shared publications - Antonio Leocata
Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy
3 shared publications Bianca Bossi
Division of Neurosurgery, Department of Biotechnology and Life Sciences University of Insubria, Ospedale di Circolo e Fondazione Macchi Varese Italy
3 shared publications- Bianca Bossi
Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Viale Luigi Borri, 57, 21100 Varese, Italy
3 shared publications - Davide Locatelli
Department of Biotechnology and Life Sciences, Division of Neurosurgery, University of Insubria, Varese, Italy
3 shared publications
Latest Publications
- Open Access
- 5 September 2026
- Published by Elsevier in Brain and Spine
- Vol. 6, 106668
Beyond the MRI-positive/MRI-negative dichotomy: A stepwise surgical strategy for Cushing's disease
- 5 September 2026
- Published by Elsevier in Brain and Spine
- Vol. 6, 106668
Open AccessBeyond the MRI-positive/MRI-negative dichotomy: A stepwise surgical strategy for Cushing's disease
- 20 May 2026
- Published by Elsevier in Neurochirurgie
- Vol. 72 (4) , 101835
Endoscopic transoral resection of retropharyngeal schwannoma: technical note and surgical considerations
- 20 May 2026
- Published by Elsevier in Neurochirurgie
- Vol. 72 (4) , 101835
Endoscopic transoral resection of retropharyngeal schwannoma: technical note and surgical considerations
- Open Access
- 18 February 2026
- Published by Elsevier in Brain and Spine
- Vol. 6
Contralateral mononostril endoscopic chopsticks technique for an intracavernous epidermoid cyst. Technical case report and systematic review of the literature
- 18 February 2026
- Published by Elsevier in Brain and Spine
- Vol. 6
Open AccessContralateral mononostril endoscopic chopsticks technique for an intracavernous epidermoid cyst. Technical case report and systematic review of the literature
- Open Access
- 7 January 2026
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 15 (2) , 482
A Simple and Cost-Effective Retractor for Transorbital Neurosurgery: Technical Note and Application in Lacrimal Keyhole Approaches
Background: Transorbital approaches (TOAs) provide minimally invasive access to anterior and middle cranial fossa lesions. However, orbital retraction remains a challenge, as narrow corridors limit maneuverability and excessive retraction increase complication risk. Conventional rigid or malleable retractors may obstruct the corridor or exert uneven pressure on delicate tissues. We present a handmade, semi-rigid plastic retractor as a low-cost, effective solution to optimize orbital retraction in TOAs. Methods: The retractor was fashioned from a cylindrical plastic drill bit container, cut into two semicircular pieces with rounded edges. Its application is described within the transorbital eyebrow lacrimal keyhole approach (TELKA). During the bony phase, one piece is placed on the orbital roof for periorbital retraction and protection, while a second may be positioned laterally to protect the temporalis muscle when required. Once adequate working space is achieved, the lateral retractor is removed and the medial one maintained throughout the procedure. Technical details are illustrated through representative clinical cases, supported by anatomical dissection and an operative video. Results: Across thirteen TELKA procedures, the semi-rigid retractor provided stable, low-intensity retraction with even pressure distribution, minimizing corridor obstruction and facilitating both microscopic and endoscopic maneuverability. No orbital or visual complications related to retraction were observed; periorbital structures were preserved, with no postoperative proptosis or aesthetic defects. Conclusions: This handmade, semi-rigid retractor is a safe, customizable, and reproducible tool that enhances surgical freedom while minimizing orbital morbidity in TOAs. It is particularly advantageous in keyhole procedures such as TELKA, representing a promising alternative to conventional retraction systems.
- 7 January 2026
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 15 (2) , 482
Open AccessA Simple and Cost-Effective Retractor for Transorbital Neurosurgery: Technical Note and Application in Lacrimal Keyhole Approaches
Background: Transorbital approaches (TOAs) provide minimally invasive access to anterior and middle cranial fossa lesions. However, orbital retraction remains a challenge, as narrow corridors limit maneuverability and excessive retraction increase complication risk. Conventional rigid or malleable retractors may obstruct the corridor or exert uneven pressure on delicate tissues. We present a handmade, semi-rigid plastic retractor as a low-cost, effective solution to optimize orbital retraction in TOAs. Methods: The retractor was fashioned from a cylindrical plastic drill bit container, cut into two semicircular pieces with rounded edges. Its application is described within the transorbital eyebrow lacrimal keyhole approach (TELKA). During the bony phase, one piece is placed on the orbital roof for periorbital retraction and protection, while a second may be positioned laterally to protect the temporalis muscle when required. Once adequate working space is achieved, the lateral retractor is removed and the medial one maintained throughout the procedure. Technical details are illustrated through representative clinical cases, supported by anatomical dissection and an operative video. Results: Across thirteen TELKA procedures, the semi-rigid retractor provided stable, low-intensity retraction with even pressure distribution, minimizing corridor obstruction and facilitating both microscopic and endoscopic maneuverability. No orbital or visual complications related to retraction were observed; periorbital structures were preserved, with no postoperative proptosis or aesthetic defects. Conclusions: This handmade, semi-rigid retractor is a safe, customizable, and reproducible tool that enhances surgical freedom while minimizing orbital morbidity in TOAs. It is particularly advantageous in keyhole procedures such as TELKA, representing a promising alternative to conventional retraction systems.
- Open Access
- 28 November 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (23) , 7229
Anterior Skull Base Reconstruction in Multiportal Approaches: Insight into Vascularized Flap Techniques
Background/Objectives: To evaluate the outcomes of anterior skull base (ASB) reconstruction using single versus double vascularized flap techniques following multiportal cranio-endoscopic approaches (CEA), based on a 12-year experience. Methods: A retrospective analysis was conducted on 46 patients who underwent ASB reconstruction after a CEA at our department between 2010 and 2022. Patients were divided into two groups: Group 1 received a pericranial flap (PF) reinforced with a fascia graft, while Group 2 underwent multiple flap reconstruction with PF, fascia graft, and nasoseptal flap (NSF). The primary outcome measured was the incidence of cerebrospinal fluid (CSF) leakage and the impact of adjuvant radiotherapy (RT) on reconstruction. Results: Group 1 (86.9%) demonstrated no significant postoperative CSF leaks, showing that the PF, combined with multilayer techniques (including underlay sealing matrix and overlay fascia graft), effectively repaired ASB defects. Group 2 (13.1%), employing both PF and NSF, showed similar outcomes, with the dual flap approach particularly beneficial in cases of post-traumatic fistulas or when the nasal septum was spared by disease. No significant differences were observed in complications or flap necrosis, even in patients receiving adjuvant RT. Conclusions: The PF is a reliable and versatile option for ASB reconstruction, often sufficient as a single-flap technique. The addition of an NSF can be beneficial in specific cases, particularly in post-traumatic conditions or tumors with unilateral endonasal invasion. However, PF alone, when combined with a multilayer approach, minimizes the risk of CSF leakage and long-term flap necrosis, underscoring the importance of tailored surgical strategies for optimal outcomes.
- 28 November 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (23) , 7229
Open AccessAnterior Skull Base Reconstruction in Multiportal Approaches: Insight into Vascularized Flap Techniques
Background/Objectives: To evaluate the outcomes of anterior skull base (ASB) reconstruction using single versus double vascularized flap techniques following multiportal cranio-endoscopic approaches (CEA), based on a 12-year experience. Methods: A retrospective analysis was conducted on 46 patients who underwent ASB reconstruction after a CEA at our department between 2010 and 2022. Patients were divided into two groups: Group 1 received a pericranial flap (PF) reinforced with a fascia graft, while Group 2 underwent multiple flap reconstruction with PF, fascia graft, and nasoseptal flap (NSF). The primary outcome measured was the incidence of cerebrospinal fluid (CSF) leakage and the impact of adjuvant radiotherapy (RT) on reconstruction. Results: Group 1 (86.9%) demonstrated no significant postoperative CSF leaks, showing that the PF, combined with multilayer techniques (including underlay sealing matrix and overlay fascia graft), effectively repaired ASB defects. Group 2 (13.1%), employing both PF and NSF, showed similar outcomes, with the dual flap approach particularly beneficial in cases of post-traumatic fistulas or when the nasal septum was spared by disease. No significant differences were observed in complications or flap necrosis, even in patients receiving adjuvant RT. Conclusions: The PF is a reliable and versatile option for ASB reconstruction, often sufficient as a single-flap technique. The addition of an NSF can be beneficial in specific cases, particularly in post-traumatic conditions or tumors with unilateral endonasal invasion. However, PF alone, when combined with a multilayer approach, minimizes the risk of CSF leakage and long-term flap necrosis, underscoring the importance of tailored surgical strategies for optimal outcomes.
- 28 October 2024
- Published by Elsevier in World Neurosurgery
- Vol. 193, 54-64
Neuroendoscopic Surgery for Intraventricular Cavernous Malformations: A Review on Indications and Surgical Considerations
- 28 October 2024
- Published by Elsevier in World Neurosurgery
- Vol. 193, 54-64
Neuroendoscopic Surgery for Intraventricular Cavernous Malformations: A Review on Indications and Surgical Considerations
- Open Access
- 22 October 2024
- Published by Wiley in Pain Practice
- Vol. 25 (1)
Preventing technique‐related complications in spinal cord stimulation trials: The Dural Substitute Confetti technique. A retrospective monocentric analysis
Background: Spinal Cord Stimulation (SCS) is an established therapy for chronic pain, employing screening trials to identify suitable candidates before implantation. However, complications arising from both technique and medical factors present challenges to this practice. This study introduces the Dural Substitute Confetti technique, which addresses technique‐related complications during SCS implantation by preventing scar‐induced lead migration or breakage and reducing operating times.Methods: We conducted a retrospective analysis on 174 patients treated with SCS trials from 2017 to 2022 at our institution. Of these, 85.1% proceeded to permanent implantation. During trial surgery, synthetic dural substitutes (DS) were used to protect leads, which remained connected to an external pulse generator (EPG) for 20–28 days (mean 21.4 days). Utilizing the DS Confetti technique, leads were easily dissected from the DS during the second surgery and connected to an internal pulse generator (IPG). We compared complications and surgical times before and after the introduction of this technique in 2017.Results: Following the complete SCS trial, patients experienced over 50% pain relief, with an implant‐to‐trial ratio of 85.1% and a mean follow‐up of 52 months. No technique‐related complications occurred during the trial period post‐2017, while the pre‐2017 group had a 3.9% lead migration rate due to scarring, necessitating re‐implantation. The average surgery duration decreased from 54 min pre‐2017 to 32 min post‐2017. Medical‐related complications included infections (2.1%) and wound dehiscence (1.3%).Conclusions: The DS Confetti technique prevents scar adhesion formation during screening trials, thereby facilitating and expediting the definitive SCS implantation. Additionally, it may also reduce the risk of lead migration and iatrogenic damage, potentially lowering technique‐related complications.
- 22 October 2024
- Published by Wiley in Pain Practice
- Vol. 25 (1)
Open AccessPreventing technique‐related complications in spinal cord stimulation trials: The Dural Substitute Confetti technique. A retrospective monocentric analysis
Background: Spinal Cord Stimulation (SCS) is an established therapy for chronic pain, employing screening trials to identify suitable candidates before implantation. However, complications arising from both technique and medical factors present challenges to this practice. This study introduces the Dural Substitute Confetti technique, which addresses technique‐related complications during SCS implantation by preventing scar‐induced lead migration or breakage and reducing operating times.Methods: We conducted a retrospective analysis on 174 patients treated with SCS trials from 2017 to 2022 at our institution. Of these, 85.1% proceeded to permanent implantation. During trial surgery, synthetic dural substitutes (DS) were used to protect leads, which remained connected to an external pulse generator (EPG) for 20–28 days (mean 21.4 days). Utilizing the DS Confetti technique, leads were easily dissected from the DS during the second surgery and connected to an internal pulse generator (IPG). We compared complications and surgical times before and after the introduction of this technique in 2017.Results: Following the complete SCS trial, patients experienced over 50% pain relief, with an implant‐to‐trial ratio of 85.1% and a mean follow‐up of 52 months. No technique‐related complications occurred during the trial period post‐2017, while the pre‐2017 group had a 3.9% lead migration rate due to scarring, necessitating re‐implantation. The average surgery duration decreased from 54 min pre‐2017 to 32 min post‐2017. Medical‐related complications included infections (2.1%) and wound dehiscence (1.3%).Conclusions: The DS Confetti technique prevents scar adhesion formation during screening trials, thereby facilitating and expediting the definitive SCS implantation. Additionally, it may also reduce the risk of lead migration and iatrogenic damage, potentially lowering technique‐related complications.
- Open Access
- 18 June 2024
- Published by Elsevier in Clinical Neurology and Neurosurgery
- Vol. 243, 108382
Endoscopic Transpterygoid Approach to Meckel’s Cave: Technical Considerations and Retrospective Analysis of a Clinical Series
- 18 June 2024
- Published by Elsevier in Clinical Neurology and Neurosurgery
- Vol. 243, 108382
Open AccessEndoscopic Transpterygoid Approach to Meckel’s Cave: Technical Considerations and Retrospective Analysis of a Clinical Series
- Open Access
- 22 February 2024
- Published by Springer Nature in Acta Neurochirurgica
- Vol. 166 (1) , 1-5
Marsupialization as an alternative to reconstruction in endoscopic skull base surgery. How I do it
Background: To treat extradural solid-cystic lesions of the ventral skull base, a pedicled nasoseptal flap (NSF) maintains patency of the marsupialized cavity and prevents restenosis and cyst recurrence. Methods: The authors provide a step-by-step description of the surgical technique valid in different lesions of the skull base, all treated via the endoscopic endonasal approach (EEA). The application is demonstrated by an operative video. Conclusion: In selected lesions, endoscopic marsupialization using an NSF ensures drainage and ventilation of the surgical cavity. Re-epithelialization provided by a pedicled flap is a viable alternative to multilayer skull base reconstruction.
- 22 February 2024
- Published by Springer Nature in Acta Neurochirurgica
- Vol. 166 (1) , 1-5
Open AccessMarsupialization as an alternative to reconstruction in endoscopic skull base surgery. How I do it
Background: To treat extradural solid-cystic lesions of the ventral skull base, a pedicled nasoseptal flap (NSF) maintains patency of the marsupialized cavity and prevents restenosis and cyst recurrence. Methods: The authors provide a step-by-step description of the surgical technique valid in different lesions of the skull base, all treated via the endoscopic endonasal approach (EEA). The application is demonstrated by an operative video. Conclusion: In selected lesions, endoscopic marsupialization using an NSF ensures drainage and ventilation of the surgical cavity. Re-epithelialization provided by a pedicled flap is a viable alternative to multilayer skull base reconstruction.