Elisa Regenhardt
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Elisa Regenhardt has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Amrei von Braun
Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, 04103 Leipzig, Germany
1 shared publication - Christoph Lübbert
Bereich Infektiologie und Tropenmedizin, Medizinische Klinik I, Universitätsklinikum Leipzig, Leipzig, Deutschland
1 shared publication - Corinna Pietsch
Institute of Virology, Leipzig University, 04103 Leipzig, Germany
1 shared publication - Holger Kirsten
Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany
1 shared publication - Mario Hönemann
Virology Department, Institute of Medical Microbiology and Virology, University of Leipzig Medical Center, Germany
1 shared publication - Melanie Weiss
Central Institution for Occupational Medicine and Occupational Safety, Leipzig University Medical Center, 04103 Leipzig, Germany
1 shared publication
Latest Publications
- Open Access
SARS-CoV-2 Vaccine Breakthrough Infections of Omicron and Delta Variants in Healthcare Workers
Understanding SARS-CoV-2 breakthrough infections in vaccinated healthcare workers is of key importance in mitigating the effects of the COVID-19 pandemic in healthcare facilities. An observational prospective cohort study was conducted in vaccinated employees with acute SARS-CoV-2 infection between October 2021 and February 2022. Serological and molecular testing was performed to determine SARS-CoV-2 viral load, lineage, antibody levels, and neutralizing antibody titers. A total of 571 (9.7%) employees experienced SARS-CoV-2 breakthrough infections during the enrolment period, of which 81 were included. The majority (n = 79, 97.5%) were symptomatic and most (n = 75, 92.6%) showed Ct values < 30 in RT-PCR assays. Twenty-four (30%) remained PCR-positive for > 15 days. Neutralizing antibody titers were strongest for the wildtype, intermediate for Delta, and lowest for Omicron variants. Omicron infections occurred at higher anti-RBD-IgG serum levels (p = 0.00001) and showed a trend for higher viral loads (p = 0.14, median Ct difference 4.3, 95% CI [−2.5–10.5]). For both variants, viral loads were significantly higher in participants with lower anti-RBD-IgG serum levels (p = 0.02). In conclusion, while the clinical course of infection with both the Omicron and Delta variants was predominantly mild to moderate in our study population, waning immune response over time and prolonged viral shedding were observed.
Open AccessSARS-CoV-2 Vaccine Breakthrough Infections of Omicron and Delta Variants in Healthcare Workers
Understanding SARS-CoV-2 breakthrough infections in vaccinated healthcare workers is of key importance in mitigating the effects of the COVID-19 pandemic in healthcare facilities. An observational prospective cohort study was conducted in vaccinated employees with acute SARS-CoV-2 infection between October 2021 and February 2022. Serological and molecular testing was performed to determine SARS-CoV-2 viral load, lineage, antibody levels, and neutralizing antibody titers. A total of 571 (9.7%) employees experienced SARS-CoV-2 breakthrough infections during the enrolment period, of which 81 were included. The majority (n = 79, 97.5%) were symptomatic and most (n = 75, 92.6%) showed Ct values < 30 in RT-PCR assays. Twenty-four (30%) remained PCR-positive for > 15 days. Neutralizing antibody titers were strongest for the wildtype, intermediate for Delta, and lowest for Omicron variants. Omicron infections occurred at higher anti-RBD-IgG serum levels (p = 0.00001) and showed a trend for higher viral loads (p = 0.14, median Ct difference 4.3, 95% CI [−2.5–10.5]). For both variants, viral loads were significantly higher in participants with lower anti-RBD-IgG serum levels (p = 0.02). In conclusion, while the clinical course of infection with both the Omicron and Delta variants was predominantly mild to moderate in our study population, waning immune response over time and prolonged viral shedding were observed.