Ahmed Abd El-Moniem Amer

Nigella sativa, commonly known as black seed, has a long history of traditional use in folk medicine. Recent scientific investigations have highlighted its significant therapeutic potential, particularly in cancer treatment. Thymoquinone, the primary bioactive compound in N. sativa, has demonstrated promising anticancer properties in numerous preclinical studies. This review comprehensively examines the current understanding of N. sativa's anticancer potential, focusing on the pharmacological actions of thymoquinone. We analyzed high-quality research articles from various databases to assess the efficacy of N. sativa and its constituents in cancer treatment. Furthermore, we explored the potential of N. sativa as an adjunct therapy within existing cancer treatment guidelines. Finally, we discuss the safety profile of N. sativa and propose future research directions to fully realize its therapeutic potential in cancer management.

Medication and food are frequently consumed together. However, some foods have interactions with medicines by changing key regulators of systemic medication availability. Their consumption is linked to interactions with a wide range of medications. One of the most significant beverages that can be harmful when combined with certain medicines is grapefruit juice. Furanocoumarins' mechanism-based suppression of intestinal cytochrome P450 3A4, which increases the bioavailability of drugs that are substrates, is the main mechanism by which interactions are mediated. There have also been reports of interactions between grapefruit products and uptake transporters such as P-glycoprotein (P-gp) and organic anion-transporting polypeptides (OATPs). It has been suggested that polyphenolic substances like flavonoids are what cause the interactions between P-gp and OATP. The amounts of furanocoumarins and flavonoids in the grapefruit product, the amount of juice consumed, the medium PH, and the inherent diversity of enzymes and transporter components in humans can all have an impact on the processes and magnitudes of interactions. In this review, we are going to shed light on clinical trials showing grapefruit juice-drug interactions and what should the health provider do for better clinical care.

Herbal teas are very common around the world. It has a good therapeutic effect. But due to adulteration, we face an obstacle to using them. The author has collected some clinical trials on commercial herbal tea formulations on the market that have proven their efficacy and safety. So, the future is for herbal medicine owing to people's psychology, minimum adverse reactions, and lower cost. The pharmaceutical manufacturing of herbal tea formulations should be encouraged to use them as add-on therapy or healthy daily beverages at least.

Migraine is a common neurological disorder that may be accompanied by vascular disturbances, Migraine is one of the most causes of disability worldwide. Zingiber officinale is a medicinal herb that has an analgesic effect on many disorders such as headaches, migraine, muscle tension, stomach spasm, and dysmenorrhea. Also, ginger has many pharmacological actions used to treat and prevent various common symptoms and diseases. This review aims to evaluate the potential of ginger to treat or prevent migraine episodes. Especially nowadays, patients prefer herbal and complementary medicine to avoid the hard side effects of chemical drugs. The author searched several databases including PubMed, Science Direct, Wiley Online, and Scopus through February 2023 for recent articles with good quality evaluating the potential of ginger to treat migraine patients. The author made investigations and Interpretations depending on the results of the authors' experiments in previous articles included in my review. It is suggested that the bioactive compounds in ginger have the potential to treat and prevent acute migraine episodes effectively and safely. The author recommends encouraging the manufacturing of different pharmaceutical dosage forms of ginger extract to be used worldwide in a safe way and to render a higher absorption rate, and pharmacological response.