Gustavo Santiso-Quinones
Gustavo Santiso-Quinones has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Doriana Timeea Ungur
Faculty of Biology and Geology, Doctoral School in Integrative Biology, Babeş-Bolyai University , 5-7 Clinicilor Street, Cluj-Napoca 400006
2 shared publications - Mihaela Maria Pop
TeraCrystal SRL, 67-103 Donat, 400293 Cluj-Napoca, Romania
2 shared publications - Alice Mija
Institut de Chimie de Nice Université Côte d’Azur Nice France
1 shared publication - Arianna Lanza
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen Ø, Denmark
1 shared publication Carmen Guguta
Technobis Crystallization Systems BV, Pyrietstraat 2, 1812 SC Alkmaar, The Netherlands
1 shared publication- Carmen Guguta
Technobis Crystallization Systems BV, Pyrietstraat 2, 1812 SC Alkmaar, The Netherlands
1 shared publication
Latest Publications
- 16 July 2024
- Published by Royal Society of Chemistry (RSC) in CrystEngComm
- Vol. 26 (32) , 4295-4304
Crystal structure of febuxostat marketed polymorph determined by electron diffraction and reinforced by X-ray crystallography
The crystal structure of the febuxostat marketed polymorph solved by ED and SC-XRD was important in understanding the compound's conformational polymorphism.
- 16 July 2024
- Published by Royal Society of Chemistry (RSC) in CrystEngComm
- Vol. 26 (32) , 4295-4304
Crystal structure of febuxostat marketed polymorph determined by electron diffraction and reinforced by X-ray crystallography
The crystal structure of the febuxostat marketed polymorph solved by ED and SC-XRD was important in understanding the compound's conformational polymorphism.
- Open Access
Febuxostat–p-Toluenesulfonic Acid Multi-Component Crystal: Characterization, Crystal Growth and Elucidation of the Salt/Co-Crystal Nature
The multi-component solid form of febuxostat (FEB) with p-toluenesulfonic acid was synthesized by solvent-drop grinding and cooling-evaporative crystallization and characterized by powder X-ray diffraction (XRPD), thermogravimetry (TGA), differential scanning calorimetry (DSC), and infrared spectroscopy (FT-IR). The multi-component form was stable after exposure at elevated temperature and relative humidity and powder dissolution measurements revealed five-fold aqueous solubility improvement relative to FEB. Additionally, the decrease in pH after dissolution suggests a potential for enhancing the drug absorption in the lower stomach. In the context of the regulatory requirements, the salt/co-crystal nature of the form was elucidated by a combination of crystallization process development and crystal growth, followed by SC-XRD and FT-IR. Despite the very weak basicity of the drug, crystal structure determination combined with spectroscopy analysis revealed salt formation by the transfer of the acidic proton from p-toluenesulfonic acid to FEB. Our study emphasizes the importance of the crystal structure knowledge in understanding the type of interactions present in multi-component crystals as well as complying with the specific regulatory requirements.
Open AccessFebuxostat–p-Toluenesulfonic Acid Multi-Component Crystal: Characterization, Crystal Growth and Elucidation of the Salt/Co-Crystal Nature
The multi-component solid form of febuxostat (FEB) with p-toluenesulfonic acid was synthesized by solvent-drop grinding and cooling-evaporative crystallization and characterized by powder X-ray diffraction (XRPD), thermogravimetry (TGA), differential scanning calorimetry (DSC), and infrared spectroscopy (FT-IR). The multi-component form was stable after exposure at elevated temperature and relative humidity and powder dissolution measurements revealed five-fold aqueous solubility improvement relative to FEB. Additionally, the decrease in pH after dissolution suggests a potential for enhancing the drug absorption in the lower stomach. In the context of the regulatory requirements, the salt/co-crystal nature of the form was elucidated by a combination of crystallization process development and crystal growth, followed by SC-XRD and FT-IR. Despite the very weak basicity of the drug, crystal structure determination combined with spectroscopy analysis revealed salt formation by the transfer of the acidic proton from p-toluenesulfonic acid to FEB. Our study emphasizes the importance of the crystal structure knowledge in understanding the type of interactions present in multi-component crystals as well as complying with the specific regulatory requirements.