Sumin Lee
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Sumin Lee has a total of 16 co-authors. Here are the top co-authors by number of shared publications:
- Sehoon Jeong
Department of Artificial Intelligence and Data Science, Sejong University, Seoul, Republic of Korea
2 shared publications - An-Gi Kim
Department of Medical Sciences, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, Republic of Korea, Seongbuk-gu, 02841, Korea (the Republic of)
1 shared publication - Dae-Hyun Seog
Department of Biochemistry, College of Medicine, Inje University, Busan 47392, Korea
1 shared publication - Deok-Gyeong Kang
Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan, Korea
1 shared publication - Dong Yun Lee
Paik Institute for Clinical Research, Inje University, Busan, Korea
1 shared publication - Gyu-Hui Lee
Paik Institute for Clinical Research, Inje University, Busan, Korea
1 shared publication
Latest Publications
- Open Access
- 10 March 2025
- Published by Korean College of Neuropsychopharmacology in Clinical Psychopharmacology and Neuroscience
- Vol. 23 (3) , 418-432
Establishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells
Mi Kyoung Seo, Sehoon Jeong, Woo Seok Cheon, Dong Yun Lee, Sumin Lee, Gyu-Hui Lee, Deok-Gyeong Kang, Dae-Hyun Seog, Seong-Ho Kim, Jung Goo Lee, Sung Woo Park. Clin Psychopharmacol Neurosci 2025;23:418-32. https://doi.org/10.9758/cpn.25.1269
- 10 March 2025
- Published by Korean College of Neuropsychopharmacology in Clinical Psychopharmacology and Neuroscience
- Vol. 23 (3) , 418-432
Open AccessEstablishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells
Mi Kyoung Seo, Sehoon Jeong, Woo Seok Cheon, Dong Yun Lee, Sumin Lee, Gyu-Hui Lee, Deok-Gyeong Kang, Dae-Hyun Seog, Seong-Ho Kim, Jung Goo Lee, Sung Woo Park. Clin Psychopharmacol Neurosci 2025;23:418-32. https://doi.org/10.9758/cpn.25.1269
- 22 May 2023
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 23 (12) , 2819-2828
Intervertebral disc organ-on-a-chip: an innovative model to study monocyte extravasation during nucleus pulposus degeneration
Degenerative cascades of the intervertebral disc (IVD) are characterized by the presence of immune cells like monocytes, macrophages, and leukocytes, which contribute to inflammation. Previous in vitro studies on monocyte chemotaxis in the presence of chemical or mechanical stimulation were unable to establish the effects of endogenous stimulating factors from resident IVD cells, or fully understand macrophage and monocyte differentiation pathways in IVD degeneration. Our study simulates monocyte extravasation using a fabricated microfluidic chemotaxis IVD organ-on-a-chip (IVD organ chip), which models the geometry of IVD, chemoattractant diffusion, and infiltration of immune cells. Additionally, the fabricated IVD organ chip mimics stepwise monocyte infiltration and differentiation into macrophages in the degenerative nucleus pulposus (NP) induced by IL-1β. We find that naïve NP cells do not recruit THP-1 monocyte-like cells, but degenerative NP cells recruit and accumulate macrophages through chemo-gradient channels. Furthermore, the differentiated and migrated THP-1 cells show phagocytic activity around inflammatory NP cells. Our in vitro model of monocyte chemotaxis with degenerative NP on an IVD organ chip depicts the sequential processes of monocyte migration/infiltration, monocyte-to-macrophage differentiation, and accumulation. Using this platform to gain a deeper understanding of monocyte infiltration and differentiation processes can provide insights into the pathophysiology of the immune response in degenerative IVD.
- 22 May 2023
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 23 (12) , 2819-2828
Intervertebral disc organ-on-a-chip: an innovative model to study monocyte extravasation during nucleus pulposus degeneration
Degenerative cascades of the intervertebral disc (IVD) are characterized by the presence of immune cells like monocytes, macrophages, and leukocytes, which contribute to inflammation. Previous in vitro studies on monocyte chemotaxis in the presence of chemical or mechanical stimulation were unable to establish the effects of endogenous stimulating factors from resident IVD cells, or fully understand macrophage and monocyte differentiation pathways in IVD degeneration. Our study simulates monocyte extravasation using a fabricated microfluidic chemotaxis IVD organ-on-a-chip (IVD organ chip), which models the geometry of IVD, chemoattractant diffusion, and infiltration of immune cells. Additionally, the fabricated IVD organ chip mimics stepwise monocyte infiltration and differentiation into macrophages in the degenerative nucleus pulposus (NP) induced by IL-1β. We find that naïve NP cells do not recruit THP-1 monocyte-like cells, but degenerative NP cells recruit and accumulate macrophages through chemo-gradient channels. Furthermore, the differentiated and migrated THP-1 cells show phagocytic activity around inflammatory NP cells. Our in vitro model of monocyte chemotaxis with degenerative NP on an IVD organ chip depicts the sequential processes of monocyte migration/infiltration, monocyte-to-macrophage differentiation, and accumulation. Using this platform to gain a deeper understanding of monocyte infiltration and differentiation processes can provide insights into the pathophysiology of the immune response in degenerative IVD.