Fazlurrahman Nawaz Khan

A dual Ru/Cu catalytic strategy has been developed for the efficient synthesis of quinoline‐appended imidazoles, benzimidazoles and quinoline‐fused γ‐lactones. This approach involved the Ru/Cu‐catalyzed oxidation and TfOH‐mediated imidazole formation. Likewise them NaBH ₄ ‐mediated cyclization under mild conditions, delivering γ‐lactones in good to excellent yields with a various substrate scope. Electrochemical studies revealed a significantly lower Δ E _p value, indicative of enhanced electron‐transfer behavior. Photophysical investigations demonstrated were pronounced aggregation‐caused quenching (ACQ) effects and further supported by particle size analysis. These findings highlight the potential of the synthesized N ‐heterocycles for their applications in sensing and optoelectronic materials.

A concise Ru/Cu-catalyzed cascade providing rapid access to pyridazinoquinolinones and late-stage N -functionalization is reported.

Deep eutectic solvents (DESs) derived from cetrimide and carboxylic acids have been used as a sustainable medium for the synthesis of quinoline-appended imidazo[1,2- a ]pyridines through cyclization and C(sp ³ )–H functionalization.

A novel approach has been developed for synthesizing papaverine and its functionalized derivatives utilizing volatile solvent-free medium. Furthermore, the photophysical properties of the functionalized papaverines were investigated.

A green protocol for the telescoped synthesis of ( E )‐2‐Aryl‐4‐styryl‐1 H ‐pyrrolo[3,4‐c]quinoline‐1,3(2 H )‐diones were developed, employing a well‐characterized deep eutectic solvent (DES) as a catalyst for a transition metal‐free cascade dehydrogenation and sp ³ C─H functionalization to yield styryl‐heterocycles ( 6a–q ). The structures of 6c, 6i, and 6ia were confirmed by single‐crystal X‐ray diffraction, and all products were analyzed by NMR, IR, and HR‐MS/GC‐MS. Photophysical properties were examined, with compound 6o showing high sensitivity for dual‐state TFA detection. Density functional theory (DFT) studies further supported experimental findings.

An efficient method has been developed for the green synthesis of alkylated quinolines via Cu‐TEMPO catalyzed dehydrogenation, and DEP/DES‐assisted benzylic C−H functionalization followed by cross Rauhut‐Currier type reaction. The reaction mechanism is elucidated through control experiments and ¹H NMR reaction monitoring. This transformation offers several advantages, including moderate to good yields of the desired products, mild reaction conditions, use of a cost‐effective metal catalyst, good functional group tolerance, and applicability to gram‐scale synthesis. Additionally, the synthetic utility and the photophysical properties of the synthesized alkylated quinoline derivatives were investigated.

An efficient and environmentally friendly one‐pot sequential synthesis of functionalized nordazepam and a benzimidazoquinazoline analogue is reported, utilizing cobalt as the metal catalyst. The reaction proceeds via either the α‐alkenylation or dehydrogenative sp³ C−H functionalization pathway. This transformation includes mild reaction conditions, operational simplicity, and good functional group tolerance. Additionally, this method is suitable for the gram‐scale synthesis of functionalized nordazepam and benzimidazoquinazoline compounds. Furthermore, the synthetic utility, photophysical properties and real‐life application of the synthesized derivatives were explored.

A facile and green chemical approach was successfully developed to construct functionalized quinolinones utilizing substituted alcohols, alkyl acetoacetate, and α-bromo ketones. Various quinolinones bearing either electron-rich or electron-deficient groups at different positions were synthesized in moderate to good yields under mild reaction conditions. The plausible mechanistic pathway for this transformation is supported by experimental evidence and control experiments. This simple approach for synthesizing quinolinones could open new avenues for discovering novel biological and pharmaceutical compounds. The use of affordable nickel catalysts, mild reaction conditions, operational simplicity, and high atom economy are attractive features of this method. Furthermore, the synthetic efficiency has been demonstrated through gram-scale experiments. Our research also provides valuable insights into the photophysical properties of the synthesized derivatives. Notably, compound 6n exhibited the highest Stokes shift (216 nm) in DCM solvent. Furthermore, compounds 5d and 6j showed positive solvatochromism, displaying a stronger emission as the solvent polarity increased. Additionally, compound 6j displayed aggregation-induced emission (AIE) properties in a DMSO : water mixture, making it suitable for use as a security ink, highlighting its potential applications in various fields.