Zhen‐Yu Yang

Water was found to be an ideal solvent for the remarkably high‐yield, fast preparation of easily hydrolyzable 2‐pyrrolecarbaldimines. In the presence of Cu²⁺, the reaction afforded, in one step, the corresponding Cu(II) chelates which were demonstrated to meet the initial set of current microelectronics criteria for Cu metal deposition via a CVD/ALD process. Electronic effects of the substituent on the imino nitrogen of the Cu complexes were shown to strongly influence the coordination geometry at the Cu center.

An automated sample preparation for high throughput accurate mass determinations by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) has been developed. Sample preparation was performed with an automated workstation and automated mass analyses were performed with a commercial MALDI‐TOF mass spectrometer. The method was tested with a 41‐sample library. MALDI‐TOFMS was found to give the needed sensitivity, accurate mass measurement, and soft ionization necessary for structure confirmation, even of mixtures. A mass accuracy of 5 ppm or less was obtained in over 80% of known compound measurements. A mass accuracy better than 10 ppm was obtained for all measurements of known compounds. Analyses of parallel synthesis products resulted in 77% of the measurements with a mass accuracy of 5 ppm or better. Copyright © 2000 John Wiley & Sons, Ltd.