Rafael Santos de Argollo Haber
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Rafael Santos de Argollo Haber has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Eduardo Federighi Baisi Chagas
Faculdade de Medicina de Marília, Brazil
1 shared publication - Jesselina Francisco dos Santos Haber
Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil
1 shared publication - José Augusto Sgarbi
Division of Endocrinology, Faculdade de Medicina de Marília, Marília 17519-030, SP, Brazil
1 shared publication - Lucas Fornari Laurindo
Division of Cellular Growth, Hemodynamic, and Homeostasis Disorders, Graduate Program in Medical Sciences, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo 01246-903, SP, Brazil
1 shared publication - Roger William de Labio
Department of Genetics, Marilia Medical School (FAMEMA), Monte Carmelo, 800-Fragata, Marília 17519-030, Brazil
1 shared publication - Sandra Maria Barbalho
Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília – UNIMAR, Brazil
1 shared publication
Latest Publications
- Open Access
- 7 April 2023
- Published by MDPI AG in Biomedicines
- Vol. 11 (4) , 1120
The Relationship between Type 1 Diabetes Mellitus, TNF-α, and IL-10 Gene Expression
Type 1 diabetes mellitus (T1DM) is one of the major chronic diseases in children worldwide. This study aimed to investigate interleukin-10 (IL-10) gene expression and tumor necrosis factor-alpha (TNF-α) in T1DM. A total of 107 patients were included, 15 were T1DM in ketoacidosis, 30 patients had T1DM and HbA1c ≥ 8%; 32 patients had T1DM and presented HbA1c < 8%; and 30 were controls. The expression of peripheral blood mononuclear cells was performed using the reverse transcriptase–polymerase chain reaction in real time. The cytokines gene expression was higher in patients with T1DM. The IL-10 gene expression increased substantially in patients with ketoacidosis, and there was a positive correlation with HbA1c. A negative correlation was found for IL-10 expression and the age of patients with diabetes, and the time of diagnosis of the disease. There was a positive correlation between TNF-α expression with age. The expression of IL-10 and TNF-α genes showed a significant increase in DM1 patients. Once current T1DM treatment is based on exogenous insulin, there is a need for other therapies, and inflammatory biomarkers could bring new possibilities to the therapeutic approach of the patients.
- 7 April 2023
- Published by MDPI AG in Biomedicines
- Vol. 11 (4) , 1120
Open AccessThe Relationship between Type 1 Diabetes Mellitus, TNF-α, and IL-10 Gene Expression
Type 1 diabetes mellitus (T1DM) is one of the major chronic diseases in children worldwide. This study aimed to investigate interleukin-10 (IL-10) gene expression and tumor necrosis factor-alpha (TNF-α) in T1DM. A total of 107 patients were included, 15 were T1DM in ketoacidosis, 30 patients had T1DM and HbA1c ≥ 8%; 32 patients had T1DM and presented HbA1c < 8%; and 30 were controls. The expression of peripheral blood mononuclear cells was performed using the reverse transcriptase–polymerase chain reaction in real time. The cytokines gene expression was higher in patients with T1DM. The IL-10 gene expression increased substantially in patients with ketoacidosis, and there was a positive correlation with HbA1c. A negative correlation was found for IL-10 expression and the age of patients with diabetes, and the time of diagnosis of the disease. There was a positive correlation between TNF-α expression with age. The expression of IL-10 and TNF-α genes showed a significant increase in DM1 patients. Once current T1DM treatment is based on exogenous insulin, there is a need for other therapies, and inflammatory biomarkers could bring new possibilities to the therapeutic approach of the patients.