Kiara Hernandez
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Kiara Hernandez has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Alberto Lázaro
Laboratorio de Fisiopatología Renal, Departamento de Nefrología, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
1 shared publication - Alexandra Roberts
Department of Biological Sciences, Bronx, Lehman College, The City University of New York, New York, NY 10468, USA
1 shared publication - Angelica Pina
Department of Biological Sciences, Bronx, Lehman College, The City University of New York, New York, NY 10468, USA
1 shared publication - Blessing V. Babalola
Department of Biological Sciences, Bronx, Lehman College, The City University of New York, New York, NY 10468, USA
1 shared publication - Johanna Bensalel
Department of Biological Sciences, Lehman College, City University of New York, Bronx, NY, 10468, United States; Ph.D. Program in Biology, The Graduate Center, City University of New York, 365 Fifth Avenue, New York, NY, 10016, United States
1 shared publication - Julio Gallego-Delgado
Department of Biological Sciences, Lehman College, The City University of New York, Bronx, New York, NY 10468, USA
1 shared publication
Latest Publications
- Open Access
Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury
The impact of malaria-associated acute kidney injury (MAKI), one of the strongest predictors of death in children with severe malaria (SM), has been largely underestimated and research in this area has been neglected. Consequently, a standard experimental mouse model to research this pathology is still lacking. The purpose of this study was to develop an in vivo model that resembles the pathology in MAKI patients. In this study, unilateral nephrectomies were performed on wild-type mice prior to infection with Plasmodium berghei NK65. The removal of one kidney has shown to be an effective approach to replicating the most common findings in humans with MAKI. Infection of nephrectomized mice, compared to their non-nephrectomized counterparts, resulted in the development of kidney injury, evident by histopathological analysis and elevated levels of acute kidney injury (AKI) biomarkers, including urinary neutrophil gelatinase-associated lipocalin, serum Cystatin C, and blood urea nitrogen. Establishment of this in vivo model of MAKI is critical to the scientific community, as it can be used to elucidate the molecular pathways implicated in MAKI, delineate the development of the disease, identify biomarkers for early diagnosis and prognosis, and test potential adjunctive therapies.
Open AccessNovel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury
The impact of malaria-associated acute kidney injury (MAKI), one of the strongest predictors of death in children with severe malaria (SM), has been largely underestimated and research in this area has been neglected. Consequently, a standard experimental mouse model to research this pathology is still lacking. The purpose of this study was to develop an in vivo model that resembles the pathology in MAKI patients. In this study, unilateral nephrectomies were performed on wild-type mice prior to infection with Plasmodium berghei NK65. The removal of one kidney has shown to be an effective approach to replicating the most common findings in humans with MAKI. Infection of nephrectomized mice, compared to their non-nephrectomized counterparts, resulted in the development of kidney injury, evident by histopathological analysis and elevated levels of acute kidney injury (AKI) biomarkers, including urinary neutrophil gelatinase-associated lipocalin, serum Cystatin C, and blood urea nitrogen. Establishment of this in vivo model of MAKI is critical to the scientific community, as it can be used to elucidate the molecular pathways implicated in MAKI, delineate the development of the disease, identify biomarkers for early diagnosis and prognosis, and test potential adjunctive therapies.