Yaein Amy Shim
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Yaein Amy Shim has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- A-Ram Kim
Research Institute, GI Biome Inc., Seongnam 13201, Republic of Korea
1 shared publication - Bo-Gie Yang
Research Institute, GI Longevity Inc., Seongnam 13201, Republic of Korea
1 shared publication - Dajeong Lee
Research Institute, GI Biome Inc., Seongnam 13201, Republic of Korea
1 shared publication - Myoung Ho Jang
Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea
1 shared publication - Seong Beom An
Research Institute, GI Biome Inc., Seongnam 13201, Republic of Korea
1 shared publication
Latest Publications
- Open Access
Degranulation of Mast Cells as a Target for Drug Development
Mast cells act as key effector cells of inflammatory responses through degranulation. Mast cell degranulation is induced by the activation of cell surface receptors, such as FcεRI, MRGPRX2/B2, and P2RX7. Each receptor, except FcεRI, varies in its expression pattern depending on the tissue, which contributes to their differing involvement in inflammatory responses depending on the site of occurrence. Focusing on the mechanism of allergic inflammatory responses by mast cells, this review will describe newly identified mast cell receptors in terms of their involvement in degranulation induction and patterns of tissue-specific expression. In addition, new drugs targeting mast cell degranulation for the treatment of allergy-related diseases will be introduced.
Open AccessDegranulation of Mast Cells as a Target for Drug Development
Mast cells act as key effector cells of inflammatory responses through degranulation. Mast cell degranulation is induced by the activation of cell surface receptors, such as FcεRI, MRGPRX2/B2, and P2RX7. Each receptor, except FcεRI, varies in its expression pattern depending on the tissue, which contributes to their differing involvement in inflammatory responses depending on the site of occurrence. Focusing on the mechanism of allergic inflammatory responses by mast cells, this review will describe newly identified mast cell receptors in terms of their involvement in degranulation induction and patterns of tissue-specific expression. In addition, new drugs targeting mast cell degranulation for the treatment of allergy-related diseases will be introduced.