Yudong Xu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Yudong Xu has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
Aibing Wang
Department of Nephrology, Qinghai Province People's Hospital, Xining, Qinghai Province, People's Republic of China
1 shared publicationHeqing Zeng
Department of Anesthesia, Hunan Wangwang Hospital, Changsha, Hunan Province, People's Republic of China
1 shared publicationJixi Wang
Department of Human Anatomy, Basic Medicine College, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China
1 shared publicationLantao Liu
Department of Human Anatomy, Basic Medicine College, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China
1 shared publicationWenhao Jiang
Department of Human Anatomy, Basic Medicine College, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China
1 shared publicationYongjie Zhu
Department of Pathology, Aksu Prefecture First People's Hospital, Aksu, Xinjiang Province, People's Republic of China
1 shared publication
Latest Publications
- Open Access
- 27 April 2012
- Published by Wiley in The Anatomical Record
- Vol. 295 (6) , 922-927
Effect of Triptolide on T‐Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen‐Induced Arthritis
Triptolide (TP) has been used in the treatment of rheumatoid arthritis (RA), but its mechanism of action is not understood. T‐cell activation and associated release of cytokines appear to be major factors in the pathogenesis of RA. The overexpression of T‐cell receptor (TCR) variable gene (V gene) fragments can cause the activation and infiltration of autoreactive T cells. This study examines the effects of TP on rats with collagen‐induced arthritis (CIA). The levels of interleukin‐10 (IL‐10) in the serum were examined with ELISA. Compared to the CIA group, the levels of IL‐10 were greater in the TP treatment group. Real‐time quantitative polymerase chain reaction confirmed that the expression of TCR V beta (BV) 15 and TCR BV19 was increased in the CIA group, whereas in the TP treatment group, the expression was decreased. In this study, TP was found to enhance IL‐10 levels and decrease the expression levels of TCR BV15 and TCR BV19. These changes might help explain the effectiveness of TP in the treatment of RA. Anat Rec, 2012.
- 27 April 2012
- Published by Wiley in The Anatomical Record
- Vol. 295 (6) , 922-927
Open AccessEffect of Triptolide on T‐Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen‐Induced Arthritis
Triptolide (TP) has been used in the treatment of rheumatoid arthritis (RA), but its mechanism of action is not understood. T‐cell activation and associated release of cytokines appear to be major factors in the pathogenesis of RA. The overexpression of T‐cell receptor (TCR) variable gene (V gene) fragments can cause the activation and infiltration of autoreactive T cells. This study examines the effects of TP on rats with collagen‐induced arthritis (CIA). The levels of interleukin‐10 (IL‐10) in the serum were examined with ELISA. Compared to the CIA group, the levels of IL‐10 were greater in the TP treatment group. Real‐time quantitative polymerase chain reaction confirmed that the expression of TCR V beta (BV) 15 and TCR BV19 was increased in the CIA group, whereas in the TP treatment group, the expression was decreased. In this study, TP was found to enhance IL‐10 levels and decrease the expression levels of TCR BV15 and TCR BV19. These changes might help explain the effectiveness of TP in the treatment of RA. Anat Rec, 2012.