Ester Lucas
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Ester Lucas has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Bibiana Quirant-Sánchez
Immunology Division, Germans Trias i Pujol University Hospital and Research Institute, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
1 shared publication - Eduard Argudo
Intensive Care Medicine Department, Vall d’Hebron University Hospital, Barcelona, Spain
1 shared publication - Eva María Martínez Cáceres
Division of Immunology, LCMN, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain
1 shared publication - Fernando Arméstar
Intensive Care Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
1 shared publication - Oriol Plans Galván
Servicio de Medicina Intensiva y Crítica, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España
1 shared publication
Latest Publications
- Open Access
- 26 June 2023
- Published by MDPI AG in Biomedicines
- Vol. 11 (7) , 1836
HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis
The reduction of mortality in patients with sepsis depends on the early identification and treatment of at-risk patients. The aim was to evaluate the HLA-DR expression on the surface of monocytes (MHLA-DR ratio), the sepsis index (CD64 expression on neutrophils/MHLA-DR ratio), and C-reactive protein (CRP) with the development of sepsis. We prospectively enrolled 77 critically ill patients, 59 with stroke and 18 with traumatic brain injuries. The biomarkers were tested at the baseline and 3, 6, 9, 12, and 15 days later. Most patients (71%) developed sepsis (4.2 ± 1.3 days after admission). On day 3, those subsequently developing sepsis had lower levels of MHLA-DR+ (81.7 ± 16.2% vs. 88.5 ± 12.1%, p < 0.05) and higher sepsis indexes (0.19 ± 0.19 vs. 0.08 ± 0.08, p < 0.01) than those not developing sepsis. The MHLA-DR ratio slowly recovered before day 6, while the sepsis index remained raised in septic patients up to day 9 (p < 0.05). To predict the development of sepsis, optimal cut-offs were CRP levels > 106.90 mg/mL (74.19% sensitivity, 69.49 specificity) and MHLA-DR expression rate < 72.80% (45.31% sensitivity, 89.47% specificity). The periodic monitoring of the MHLA-DR expression together with CRP and sepsis index may help to identify patients in the ICU at increased risk of developing sepsis.
- 26 June 2023
- Published by MDPI AG in Biomedicines
- Vol. 11 (7) , 1836
Open AccessHLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis
The reduction of mortality in patients with sepsis depends on the early identification and treatment of at-risk patients. The aim was to evaluate the HLA-DR expression on the surface of monocytes (MHLA-DR ratio), the sepsis index (CD64 expression on neutrophils/MHLA-DR ratio), and C-reactive protein (CRP) with the development of sepsis. We prospectively enrolled 77 critically ill patients, 59 with stroke and 18 with traumatic brain injuries. The biomarkers were tested at the baseline and 3, 6, 9, 12, and 15 days later. Most patients (71%) developed sepsis (4.2 ± 1.3 days after admission). On day 3, those subsequently developing sepsis had lower levels of MHLA-DR+ (81.7 ± 16.2% vs. 88.5 ± 12.1%, p < 0.05) and higher sepsis indexes (0.19 ± 0.19 vs. 0.08 ± 0.08, p < 0.01) than those not developing sepsis. The MHLA-DR ratio slowly recovered before day 6, while the sepsis index remained raised in septic patients up to day 9 (p < 0.05). To predict the development of sepsis, optimal cut-offs were CRP levels > 106.90 mg/mL (74.19% sensitivity, 69.49 specificity) and MHLA-DR expression rate < 72.80% (45.31% sensitivity, 89.47% specificity). The periodic monitoring of the MHLA-DR expression together with CRP and sepsis index may help to identify patients in the ICU at increased risk of developing sepsis.