Salwa R. El-Shaboury
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Salwa R. El-Shaboury has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Azza H. Rageh
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
1 shared publication Fardous A. Mohamed
Department of Pharmaceutical Analytical Chemistry, Facutly of Pharmacy, Assiut Univeristy , 71526 Assiut, Egypt
1 shared publicationGamal A. Saleh
Department of Pharmaceutical Analytical Chemistry, Facutly of Pharmacy, Assiut Univeristy, 71526 Assiut, Egypt
1 shared publication
Latest Publications
- Open Access
- 1 January 2010
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 48 (1) , 68-75
Selective Densitometric Determination of Four -Aminocephalosporins Using Ninhydrin Reagent
A simple, selective, and precise densitometric method for analysis of four α-aminocephalosporins, namely cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous, and cefradine anhydrous, both in bulk drugs and in formulations was developed and validated. The method employed thin-layer chromatography (TLC) aluminium sheets precoated with silica gel G 60 F254 as the stationary phase. The solvent system consists of ethyl acetate-methanol-water with different ratios for all studied drugs (Rf values of 0.40–0.60). The separated spots were visualized as blue to violet color after spraying with ninhydrin reagent. The linear regression analysis data for the calibration plots of all studied drugs produced a good linear relationship with correlation coefficients ranging from 0.9990 to 0.9996 and coefficients of determination ranging from 0.9986 to 0.9992 over the concentration range 2–10 µg/spot. The limits of detection and quantitation for all studied drugs ranged from 0.09 to 0.23 and from 0.27 to 0.84 µg/spot, respectively. The developed method was applied successfully for the determination of the studied drugs in their pharmaceutical dosage forms with good precision and accuracy. Also, the method can be employed as a promising stability-indicating assay.
- 1 January 2010
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 48 (1) , 68-75
Open AccessSelective Densitometric Determination of Four -Aminocephalosporins Using Ninhydrin Reagent
A simple, selective, and precise densitometric method for analysis of four α-aminocephalosporins, namely cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous, and cefradine anhydrous, both in bulk drugs and in formulations was developed and validated. The method employed thin-layer chromatography (TLC) aluminium sheets precoated with silica gel G 60 F254 as the stationary phase. The solvent system consists of ethyl acetate-methanol-water with different ratios for all studied drugs (Rf values of 0.40–0.60). The separated spots were visualized as blue to violet color after spraying with ninhydrin reagent. The linear regression analysis data for the calibration plots of all studied drugs produced a good linear relationship with correlation coefficients ranging from 0.9990 to 0.9996 and coefficients of determination ranging from 0.9986 to 0.9992 over the concentration range 2–10 µg/spot. The limits of detection and quantitation for all studied drugs ranged from 0.09 to 0.23 and from 0.27 to 0.84 µg/spot, respectively. The developed method was applied successfully for the determination of the studied drugs in their pharmaceutical dosage forms with good precision and accuracy. Also, the method can be employed as a promising stability-indicating assay.