Hiyoung Kim
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Hiyoung Kim has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Dong Hwan Won
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea
1 shared publication - Heonjoong Kang
Seoul National University
1 shared publication - Hyukjae Choi
College of Pharmacy, Yeungnam University, Gyeongsan-si 38541, Gyeongsangbukdo, Republic of Korea
1 shared publication - Jeong-Tae Yeon
Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea
1 shared publication - Kwang-Jin Kim
Department of Pharmacy, Sunchon National University, Jeonnam, Suncheon 57922, Korea
1 shared publication - Sang-Jip Nam
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea
1 shared publication
Latest Publications
- Open Access
- 3 April 2014
- Published by MDPI AG in Marine Drugs
- Vol. 12 (4) , 2054-2065
Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
- 3 April 2014
- Published by MDPI AG in Marine Drugs
- Vol. 12 (4) , 2054-2065
Open AccessPlacotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.