Jin Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Research Interests
Jin Yang has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
Dongping Yuan
First Affiliated Hospital of Nanjing Medical University, Nanjing, China
1 shared publicationJunjie Zou
First Affiliated Hospital of Nanjing Medical University, Nanjing, China
1 shared publication- Yun Yu
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
1 shared publication
Latest Publications
- Open Access
- 22 February 2022
- Published by Frontiers Media SA in Frontiers in Nutrition
- Vol. 9, 831485
Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction
At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases.
- 22 February 2022
- Published by Frontiers Media SA in Frontiers in Nutrition
- Vol. 9, 831485
Open AccessEffects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction
At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases.